bis[(Z)-non-2-enyl] 9-[2-[(E)-[5-(dimethylamino)-3,4-dimethylpentylidene]amino]oxy-2-oxoethyl]heptadecanedioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: bis[(Z)-non-2-enyl] 9-[2-[(E)-[5-(dimethylamino)-3,4-dimethylpentylidene]amino]oxy-2-oxoethyl]heptadecanedioate
• 化学式: C₄₆H₈₄N₂O₆
• 分子量: 761.2
• InChiKey: WZFLRTSAPIWKPQ-PJBSJYMMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  54
• 可旋转键数：
  41
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  94.5
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS<br/>[FR] LIPIDES BIODÉGRADABLES POUR L'ADMINISTRATION DE PRINCIPES ACTIFS
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2011153493A2

  公开（公告）日：2011-12-08

  The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
• [EN] IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS<br/>[FR] FORMULATIONS DE PARTICULES LIPIDIQUES D'ACIDE NUCLÉIQUE AMÉLIORÉES
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2014089239A1

  公开（公告）日：2014-06-12

  The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA. In addition to the biodegradable cationic lipid the nanoparticles comprise a non-cationic lipid, polyethylne glycol dipalmitoylglycerol (PEG-DPG) and optionally a sterol.