8-(5-cyclopropylpyrazin-2-yl)oxy-2-[[4-(trifluoromethyl)phenyl]methyl]-4,5,7,8,9,9a-hexahydro-3H-pyrrolo[1,2-a][1,4]diazepin-1-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 8-(5-cyclopropylpyrazin-2-yl)oxy-2-[[4-(trifluoromethyl)phenyl]methyl]-4,5,7,8,9,9a-hexahydro-3H-pyrrolo[1,2-a][1,4]diazepin-1-one
• 化学式: C₂₃H₂₅F₃N₄O₂
• 分子量: 446.5
• InChiKey: LHHQOSPIANWCQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN
  申请人：Abbvie Inc.

  公开号：EP2931727A1

  公开（公告）日：2015-10-21
• [EN] DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN<br/>[FR] DÉRIVÉS DE DIAZÉPINE UTILES COMME INHIBITEURS DES CANAUX CALCIQUES DANS LE TRAITEMENT DE LA DOULEUR
  申请人：ABBVIE INC

  公开号：WO2014093337A1

  公开（公告）日：2014-06-19

  This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain. Formula (I). Further disclosed are (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.