[1-[2-[[5-acetamido-6-[[1-[[1-formyloxy-2-(1H-imidazol-5-yl)ethyl]amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]amino]ethoxy-hydroxyphosphoryl]oxy-3-propanoyloxypropan-2-yl] butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [1-[2-[[5-acetamido-6-[[1-[[1-formyloxy-2-(1H-imidazol-5-yl)ethyl]amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]amino]ethoxy-hydroxyphosphoryl]oxy-3-propanoyloxypropan-2-yl] butanoate
• 化学式: C₂₉H₄₉N₆O₁₃P
• 分子量: 720.7
• InChiKey: AWZULBMVAFUSEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  49
• 可旋转键数：
  29
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  263
• 氢给体数：
  6
• 氢受体数：
  15

文献信息

• AMPHOTERIC LIPOSOMES COMPRISING NEUTRAL LIPIDS
  申请人：Marina Biotech, Inc.

  公开号：US20140178462A1

  公开（公告）日：2014-06-26

  An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mixtures is 0.3 or less. Said amphoteric liposome may encapsulate an active agent, such as nucleic acid therapeutics. Also disclosed are pharmaceutical compositions comprising said amphoteric liposomes as a carrier for the delivery or targeted delivery of active agents or ingredients.
• COMPONENTS FOR PRODUCING AMPHOTERIC LIPOSOMES
  申请人：Marina Biotech, Inc.

  公开号：US20140227345A1

  公开（公告）日：2014-08-14

  The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds.
• US9668973B2
  申请人：——

  公开号：US9668973B2

  公开（公告）日：2017-06-06