carboxamidomethyloxyamine hydrochloride | 54488-65-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: carboxamidomethyloxyamine hydrochloride
• 英文别名: 2-(Aminooxy)acetamide hydrochloride；2-aminooxyacetamide;hydrochloride
• CAS: 54488-65-2
• 化学式: C₂H₆N₂O₂*ClH
• mdl: MFCD01745738
• 分子量: 126.543
• InChiKey: BIUQVFWWPLIJJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.69
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  78.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diphenylmethyl (2S,3R,5R)-3-formyl-3-methyl-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 、 carboxamidomethyloxyamine hydrochloride 在 吡啶 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 10.0h， 以16%的产率得到diphenylmethyl (2S,3R,5R)-3-(carbamoylmethoxyimino)methyl-3-methyl-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate
  参考文献：
  名称：

  Synthesis and biological evaluation of penam sulfones as inhibitors of β-lactamases

  摘要：

  The chemical synthesis of a series of new penam sulfone derivatives bearing a 2 beta-substituted-oxyimino and -hydrazone substituents, their beta-lactamase inhibitory properties against selected enzymes representing class A and C beta-lactamases are reported. The oxime containing pertain sulfones strongly inhibited the Escherichia coli TEM-1 and Klebsiella pneumoniae cefotaximase (CTX-1) enzymes, but moderately inhibited the Pseudomonas aeruginosa 46012 cephalosporinase; while the 2 beta-substituted-hydrazone derivatives were generally less active against these enzymes. Furthermore, most of the inhibitors enhanced the antibacterial activities of piperacillin (PIP) and ceftazidime (CAZ) particularly against TEM-1 and CTX-1 producing bacterial strains. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.02.020

文献信息

• COMPOSITION COMPRISING ANTIBIOTIC COMPOUND AND AN HETEROCYCLIC COMPOUND AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS
  申请人：Mutabilis

  公开号：EP3300736B1

  公开（公告）日：2021-05-05