3-[3-[[8-[4-[2-[3-[3-[3-(3-Ethoxypropoxy)propoxy]propoxy]propoxy]ethoxy]phenyl]-2-methoxy-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-8-(4-methoxyphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 3-[3-[[8-[4-[2-[3-[3-[3-(3-Ethoxypropoxy)propoxy]propoxy]propoxy]ethoxy]phenyl]-2-methoxy-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-8-(4-methoxyphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• 英文别名: 3-[3-[[8-[4-[2-[3-[3-[3-(3-ethoxypropoxy)propoxy]propoxy]propoxy]ethoxy]phenyl]-2-methoxy-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-8-(4-methoxyphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• 化学式: C₅₈H₇₀N₄O₁₃
• 分子量: 1031.2
• InChiKey: VKLNTHGVQYZSPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  75
• 可旋转键数：
  32
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  167
• 氢给体数：
  0
• 氢受体数：
  15

文献信息

• Methods of preparing antibody-active agent conjugates
  申请人：LegoChem Biosciences, Inc.

  公开号：US20140187756A1

  公开（公告）日：2014-07-03

  The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agent. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods.