(4S)-4-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-[[(1S)-1-carboxybut-3-ynyl]amino]-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4S)-4-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-[[(1S)-1-carboxybut-3-ynyl]amino]-5-oxopentanoic acid
• 化学式: C₂₄H₂₄N₈O₇
• 分子量: 536.5
• InChiKey: VVPWMGPVZWAPSE-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  238
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• 18F-SACCHARIDE-FOLATES
  申请人：Schibli Roger

  公开号：US20140193337A1

  公开（公告）日：2014-07-10

  The present invention is directed towards new 18 F-folate radiopharmaceuticals, wherein the 18 F isotope is linked via a prosthetic group, more specifically via a prosthetic group having a saccharide group, such as a cyclic mono- or oligosaccharide, preferably based on a pyranoside or furanoside, which is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

  本发明涉及新的18F-叶酸类放射性药物，其中18F同位素通过一个假体基团连接，更具体地说是通过一个带有糖苷基团的假体基团连接，比如基于吡喃苷或呋喃苷的环状单糖或寡糖，该基团共价连接到叶酸或其衍生物的谷氨酸部分，以及它们的制备方法，以及在癌症、炎症性和自身免疫性疾病的诊断和监测以及治疗中的使用。
• 18F-saccharide-folates
  申请人：Schibli Roger

  公开号：US10322195B2

  公开（公告）日：2019-06-18

  The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the 18F isotope F is linked via a prosthetic group, more specifically via a prosthetic group having a saccharide group, such as a cyclic mono- or oligosaccharide, preferably based on a pyranoside or furanoside, which is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

  本发明旨在开发新的 18F 叶酸放射性药物，其中 18F 同位素 F 通过人工基团连接，更具体地说，是通过具有糖基（如环状单糖或寡糖，最好是基于吡喃糖苷或呋喃糖苷）的人工基团连接，该人工基团与叶酸或其衍生物的谷氨酸部分共价连接，本发明还涉及其制备方法以及在癌症、炎症性和自身免疫性疾病的诊断和监测及其治疗中的用途。