N-[(E,2R,3R)-1-hydroxy-3-methyloctadec-4-en-2-yl]octadecanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-[(E,2R,3R)-1-hydroxy-3-methyloctadec-4-en-2-yl]octadecanamide
• 化学式: C₃₇H₇₃NO₂
• 分子量: 564.0
• InChiKey: KYYFIDGEKDRUBZ-WOELGCADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.4
• 重原子数：
  40
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE
  申请人：Genzyme Corporation

  公开号：US20160120842A1

  公开（公告）日：2016-05-05

  The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
• US8779163B2
  申请人：——

  公开号：US8779163B2

  公开（公告）日：2014-07-15