[1-(5-Nitro-2,3-dihydrofuro[2,3-b]pyridin-4-yl)-5-(trifluoromethyl)piperidin-3-yl]carbamic acid

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: [1-(5-Nitro-2,3-dihydrofuro[2,3-b]pyridin-4-yl)-5-(trifluoromethyl)piperidin-3-yl]carbamic acid
• 英文别名: [1-(5-nitro-2,3-dihydrofuro[2,3-b]pyridin-4-yl)-5-(trifluoromethyl)piperidin-3-yl]carbamic acid
• 化学式: C14H15F3N4O5
• 分子量: 376.29
• InChiKey: GPAQWFCOFQNULL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
  申请人：Incyte Corporation

  公开号：EP2945939A1

  公开（公告）日：2015-11-25
• [EN] THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS<br/>[FR] COMPOSÉS DE THIAZOLECARBOXAMIDE ET DE PYRIDINECARBOXAMIDE UTILES COMME INHIBITEURS DE KINASES PIM
  申请人：INCYTE CORP

  公开号：WO2014113388A1

  公开（公告）日：2014-07-24

  The present disclosure describes thiazole and pyridine carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein: X is C or N; A, B and D are rings; the bond— represents a normalized bond within the aromatic ring containing both an N and X, which formally is represented by a C=C bond when X is C and a single bond when X is N; ring A is of the formula (A-l) or (A-2): wherein El and E2 are rings; their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.