(3S)-3-methyl-4-[(2S)-4-methyl-2-[(3S)-3-(2-methylpropyl)-2-oxopiperazin-1-yl]pentanoyl]-1-[(2S)-3-oxobutan-2-yl]piperazin-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-3-methyl-4-[(2S)-4-methyl-2-[(3S)-3-(2-methylpropyl)-2-oxopiperazin-1-yl]pentanoyl]-1-[(2S)-3-oxobutan-2-yl]piperazin-2-one
• 化学式: C₂₃H₄₀N₄O₄
• 分子量: 436.6
• InChiKey: ZJGNTTNFDHLAKC-ZULIPRJHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• OLIGOOXOPIPERAZINES FOR p53 REACTIVATION
  申请人：New York University

  公开号：US20140205655A1

  公开（公告）日：2014-07-24

  The present invention relates to oligooxopiperazines for reactivating p53. Methods of using the oligooxopiperazines are also disclosed.

  本发明涉及用于重新激活p53的寡聚氧杂螺环。本发明还公开了使用寡聚氧杂螺环的方法。
• CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS
  申请人：ARORA Paramjit S.

  公开号：US20160297802A1

  公开（公告）日：2016-10-13

  The present invention relates to oligooxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
• US9695153B2
  申请人：——

  公开号：US9695153B2

  公开（公告）日：2017-07-04