(3S,5S)-5-[(2S,4R)-4-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-5-methylhexan-2-yl]-3-propan-2-yloxolan-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3S,5S)-5-[(2S,4R)-4-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-5-methylhexan-2-yl]-3-propan-2-yloxolan-2-one
• 化学式: C₂₆H₄₂O₅
• 分子量: 434.6
• InChiKey: QEZWKHIJRUYTOM-OHCHIEETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• CHEMICAL PROCESS FOR OPENING RING COMPOUNDS
  申请人：Carcone Luca

  公开号：US20140213821A1

  公开（公告）日：2014-07-31

  It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products.