3,3-Bis(carboxymethyl)cyclopentane-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,3-Bis(carboxymethyl)cyclopentane-1-carboxylic acid
• 英文别名: 3,3-bis(carboxymethyl)cyclopentane-1-carboxylic acid
• 化学式: C₁₀H₁₄O₆
• 分子量: 230.21
• InChiKey: JZYYIXGDEWTYHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] TRANSFORMATION OF DRUG CYCLODEXTRIN COMPLEX COMPOSITIONS INTO COMPOSITIONS OF MIXTURES OF LIPID VESICLE ENCAPSULATED DRUG AND CYCLODEXTRIN DRUG COMPLEXES<br/>[FR] TRANSFORMATION DE COMPOSITIONS DE TYPE COMPLEXE MÉDICAMENT-CYCLODEXTRINE EN COMPOSITIONS CONSTITUÉES DE MÉLANGES DE MÉDICAMENT ENCAPSULÉ DANS DES VÉSICULES LIPIDIQUES ET DE COMPLEXES CYCLODEXTRINE-MÉDICAMENT
  申请人：ZONEONE PHARMA INC

  公开号：WO2014121235A2

  公开（公告）日：2014-08-07

  Sparingly water-soluble agents can be formulated as cyclodextrin complexes, however, these water-soluble drug-cyclodextrin complexes dissociate when the complex is administered into patients. The dilution of the complex in the patient leads to the drug being released from the complex, so the drug is not effectively targeted. In contrast, drugs encapsulated in the aqueous core of a lipid vesicles are not released when the liposome is diluted in blood. This invention describes compositions and methods whereby cyclodextrin or polyanionic beta- cyclodextrin drug-complexes are mixed with a preformed liposome containing the amine salts of an acidic compound. This results in the drug cyclodextrin complex being transferred into the liposome where it is stably retained. The liposome-encapsulated drug can then be injected into a patient.