2-[[1-(Carboxymethyl)piperidin-4-yl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[1-(Carboxymethyl)piperidin-4-yl]amino]propanoic acid
• 英文别名: 2-[[1-(carboxymethyl)piperidin-4-yl]amino]propanoic acid
• 化学式: C₁₀H₁₈N₂O₄
• 分子量: 230.26
• InChiKey: NGQCSUNBDAMHPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] PRETARGETED ACTIVATABLE CELL PENETRATING PEPTIDE WITH INTRACELLULARY RELEASEABLE PRODRUG<br/>[FR] PEPTIDE À PÉNÉTRATION CELLULAIRE ACTIVABLE PRÉ-CIBLÉ COMPORTANT UN PROMÉDICAMENT À LIBÉRATION INTRACELLULAIRE
  申请人：UNIV CALIFORNIA

  公开号：WO2014120837A2

  公开（公告）日：2014-08-07

  Disclosed herein, the invention pertains to methods and compositions that find use in treatment, diagnosis, prognosis and characterization of disease and disease samples based on the ability of a disease sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is a pre-targeting moiety; M is a macromolecular carrier; C is a detectable moiety; and T is a compound for delivery to a target, including for example a therapeutic compound.