2-(Deuterioamino)dodecanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Deuterioamino)dodecanoic acid
• 英文别名: 2-(deuterioamino)dodecanoic acid
• 化学式: C12H25NO2
• 分子量: 216.34
• InChiKey: QUBNFZFTFXTLKH-DYCDLGHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• AUTOPHAGY-INDUCING PEPTIDE ANALOGS
  申请人：The Board of Regents, University of Texas System

  公开号：EP2976353B1

  公开（公告）日：2018-12-26
• US8802633B1
  申请人：——

  公开号：US8802633B1

  公开（公告）日：2014-08-12
• [EN] METHODS AND COMPOSITIONS<br/>[FR] MÉTHODES ET COMPOSITIONS
  申请人：UNIV MONASH

  公开号：WO2021212168A1

  公开（公告）日：2021-10-28

  Methods of stimulating muscle regeneration, comprising delivering to a muscle a CCR5 interacting agent or encoding molecule. The CCR5 interacting agent binds to muscle stem cells and stimulates myoblast proliferation and muscle regeneration. One example of the CCR5 interacting agent is NAMPT comprising a cytokine finger motif or a derivative thereof. Methods and compositions include cellular compositions, which expresses the CCR5 interacting agent; including a population of satellite or macrophage cells or their precursors/progeny and their applications in stem cell therapy or for use in treating a muscular deficiency, disorder or injury. The examples show muscle tissue regeneration with minimal fibrosis. Also enabled is a NAMPT polypeptide fragment comprising a C-terminal portion of NAMPT comprising a cytokine finger. Compositions further comprise the NAMPT polypeptide fragment and one or more of; tissue stem cell or macrophage or precursor/progeny, scaffold or a retentive material, tissue delivery enhancing or cell retention moiety.