5-(2,3-dimetoxyphenyl)-cyclohexane-1,3-dione | 192431-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2,3-dimetoxyphenyl)-cyclohexane-1,3-dione
• 英文别名: 5-(2,3-Dimethoxyphenyl)cyclohexane-1,3-dione；5-(2,3-dimethoxyphenyl)cyclohexane-1,3-dione
• CAS: 192431-82-6
• 化学式: C₁₄H₁₆O₄
• mdl: MFCD23555867
• 分子量: 248.279
• InChiKey: FHVKUPOFWPTOBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(2,3-dimetoxyphenyl)-cyclohexane-1,3-dione 在 双氧水 、 溶剂黄146 作用下， 以 二甲基亚砜 为溶剂， 反应 3.5h， 生成 7-chloro-1,2-dihydro-2-(2,3-dimethoxyphenyl)-4(3H,10H)-phenothiazinone 5,5-dioxide
  参考文献：
  名称：

  Synthesis and Antimalarial Effects of Phenothiazine Inhibitors of a Plasmodium falciparum Cysteine Protease

  摘要：

  Acridinediones have previously been shown to have potent antimalarial activity. A series of sulfur isosteres of acridinediones Slave been synthesized and evaluated for their inhibition of the Plasmodium falciparum cysteine protease falcipain and for their antimalarial activity. A number of these phenothiazines inhibited falcipain and demonstrated activity against cultured P, falciparum parasites at low micromolar concentrations. Wie propose that the compounds exerted their antimalarial effects by two mechanisms, one of which involves the inhibition of falcipain and a consequent block in parasite degradation of hemoglobin. These compounds and related phenothiazines are worthy of further study as potential antimalarial agents.

  DOI：

  10.1021/jm970266p

文献信息

• [EN] INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE<br/>[FR] INHIBITEURS DE LA CYSTATHIONINE BÊTA SYNTHASE UTILISABLES EN VUE DE LA RÉDUCTION DE LA SURPRODUCTION NEUROTOXIQUE DE SULFURE D'HYDROGÈNE ENDOGÈNE
  申请人：FOND JEROME LEJEUNE

  公开号：WO2013068592A1

  公开（公告）日：2013-05-16

  The invention is directed to inhibitors of cystathionine beta synthase which, among other biochemical effects, allow reduction of the neurotoxic overproduction of endogenous hydrogen sulphide. These compounds and pharmaceutical compositions containing them are useful for the prevention and treatment of cognitive disorders such as cognitive disorders in Down syndrome. The invention also relates to methods for preventing or treating cognitive disorders including cognitive disorders in Down Syndrome.

  本发明涉及胱硫醚β合酶抑制剂，除其他生化作用外，还允许减少内源性硫化氢的神经毒性过度产生。这些化合物以及含有它们的药物组合物对于预防治疗认知障碍，如下氏综合症中的认知障碍等是有用的。本发明还涉及用于预防或治疗认知障碍的方法，包括下氏综合症中的认知障碍。