US9433622, Dmx-156

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: US9433622, Dmx-156
• 英文别名: 3-[(3S)-3-fluoropyrrolidin-1-yl]-6-[2-[[6-[(3-oxopiperazin-1-yl)methyl]pyridin-3-yl]amino]pyrimidin-4-yl]pyridine-2-carbonitrile
• 化学式: C₂₄H₂₄FN₉O
• 分子量: 473.5
• InChiKey: XRQJOYVRPVUISO-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  3-((S)-3-Fluoro-pyrrolidin-1-yl)-6-[2-(6-hydroxymethyl-pyridin-3-ylamino)-pyrimidin-4-yl]-pyridine-2-carbonitrile 、 三溴化磷 、 2-哌嗪酮 在 甲醇 作用下， 以 乙腈 为溶剂， 反应 16.5h， 以The title compound (3 mg, 6%) was obtained as an off-white solid的产率得到US9433622, Dmx-156
  参考文献：
  名称：

  Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms

  摘要：

  一般式（I）的化合物及其盐在治疗与蛋白激酶IKKε和/或TBK-1的异常活性相关的疾病中有用，其中V和W中的一个是N，另一个是C-H；R1，R2，R3和R4如规范所定义。本发明还提供了化合物的用途和含有它们的组合物。

  公开号：

  US09433622B2

文献信息

• Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms
  申请人：DOMAINEX LIMITED

  公开号：US09433622B2

  公开（公告）日：2016-09-06

  Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases IKKε and/or TBK-1 in which one of V and W is N, and the other of V and W is C—H; and R1, R2, R3 and R4 are as defined in the specification. The invention also provides uses of the compounds and compositions containing them.

  一般式（I）的化合物及其盐在治疗与蛋白激酶IKKε和/或TBK-1的异常活性相关的疾病中有用，其中V和W中的一个是N，另一个是C-H；R1，R2，R3和R4如规范所定义。本发明还提供了化合物的用途和含有它们的组合物。
• US9433622B2
  申请人：——

  公开号：US9433622B2

  公开（公告）日：2016-09-06
• [EN] PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS<br/>[FR] COMPOSÉS PYRIMIDINE UTILES DANS LE TRAITEMENT DE MALADIES MÉDIÉES PAR LES MÉCANISMES DES IKK&Egr; ET/OU TBK-1
  申请人：DOMAINEX LTD

  公开号：WO2014128486A1

  公开（公告）日：2014-08-28

  Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases ΙΚΚε and/or TBK-1 in which one of V and W is N, and the other of V and W is C-H; and R1, R2, R3 and R4 are as defined in the specification. The invention also provides uses of the compounds and compositions containing them.
• PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS
  申请人：DOMAINEX LIMITED

  公开号：US20160000784A1

  公开（公告）日：2016-01-07

  Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases IKKε and/or TBK-1 in which one of V and W is N, and the other of V and W is C—H; and R 1 , R 2 , R 3 and R 4 are as defined in the specification. The invention also provides uses of the compounds and compositions containing them.

  通式（I）及其盐在治疗与蛋白激酶IKKε和/或TBK-1的异常活性相关的疾病方面具有用处，其中V和W中的一个是N，另一个是C-H；R1、R2、R3和R4如规范中定义。本发明还提供了化合物的用途和含它们的组合物。