莫托替尼二盐酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 莫托替尼二盐酸盐
• 英文名称: N-(cyanomethyl)-4-[2-(4-morpholin-4-ium-4-ylanilino)pyrimidin-1-ium-4-yl]benzamide;dichloride
• 化学式: C23H24Cl2N6O2
• 分子量: 487.4
• InChiKey: IPNATXQRPWRHKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  103
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• (N-(CYANOMETHYL)-4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE
  申请人：Gilead Sciences, Inc.

  公开号：US20150361050A1

  公开（公告）日：2015-12-17

  The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.

  本发明涉及N-(氰甲基)-4-(2-(4-吗啉基苯氨基)嘧啶-4-基)苯甲酰的稳定新盐形式，适用于制备药物配方，并用于治疗。
• PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF
  申请人：Burns Christopher John

  公开号：US20100197671A1

  公开（公告）日：2010-08-05

  The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

  本发明涉及苯基氨基嘧啶化合物，它们是蛋白激酶抑制剂，包括JAK激酶。特别是，这些化合物对JAK2激酶具有选择性。这些激酶抑制剂可用于治疗与激酶相关的疾病，如免疫和炎症性疾病，包括器官移植；增生性疾病，包括癌症和骨髓增生性疾病；病毒性疾病；代谢性疾病；以及血管性疾病。
• Combinations comprising MABA compounds and corticosteroids
  申请人：ALMIRALL, S.A.

  公开号：US10456390B2

  公开（公告）日：2019-10-29

  A combination which comprises (a) corticosteroid and (b) a dual muscarinic antagonist-β2 adrenergic agonist compound, or any pharmaceutically acceptable salt or solvate thereof.

  由(a)皮质类固醇和(b)双重毒蕈碱拮抗剂-β2 肾上腺素能激动剂化合物或其任何药学上可接受的盐或溶液组成的组合物。
• DEUTERATED MOMELOTINIB
  申请人：Concert Pharmaceuticals Inc.

  公开号：EP2943489A1

  公开（公告）日：2015-11-18
• COMBINATIONS COMPRISING MABA COMPOUNDS AND CORTICOSTEROIDS
  申请人：Almirall S.A.

  公开号：EP2988745A1

  公开（公告）日：2016-03-02