6-Oxa-octadecandicarbonsaeure | 16889-83-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-Oxa-octadecandicarbonsaeure
• 英文别名: 13-(3-Carboxypropoxy)tridecanoic acid；13-(3-carboxypropoxy)tridecanoic acid
• CAS: 16889-83-1
• 化学式: C₁₇H₃₂O₅
• 分子量: 316.438
• InChiKey: XLFGFRBDHMSUPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• ANTIBIOTIC CONJUGATES LINKED WITH STEROID DRUGS
  申请人：ALLERGAN, INC.

  公开号：EP2964267A1

  公开（公告）日：2016-01-13
• CYCLOSPORINE A-STEROID CONJUGATES
  申请人：ALLERGAN, INC.

  公开号：EP2964269A1

  公开（公告）日：2016-01-13
• [EN] ANTIBIOTIC CONJUGATES LINKED WITH STEROID DRUGS<br/>[FR] CONJUGUÉS ANTIBIOTIQUES LIÉS À DES MÉDICAMENTS STÉROÏDES
  申请人：ALLERGAN INC

  公开号：WO2014138375A1

  公开（公告）日：2014-09-12

  The present invention describes novel single drug entities, formed by the linkage of an antibiotic with a steroidal drug via a linker. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
• [EN] CYCLOSPORINE A-STEROID CONJUGATES<br/>[FR] CONJUGUÉS STÉROÏDE/CYCLOSPORINE A
  申请人：ALLERGAN INC

  公开号：WO2014138425A1

  公开（公告）日：2014-09-12

  The present invention describes Cyclosporine A/steroid hybrid analogs. These single drug entities are formed by connecting a steroid with Cyclosporine A. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
• [EN] STEROID CONJUGATES<br/>[FR] CONJUGUÉS DE STÉROÏDES
  申请人：ALLERGAN INC

  公开号：WO2014138437A1

  公开（公告）日：2014-09-12

  The present invention describes steroid conjugates. These single drug entities are formed by connecting two or more steroids via a linker. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual steroid drugs.