6-(3-Azidopropoxycarbonylamino)-2-[3-(iminoazaniumylideneamino)propoxycarbonylamino]hexanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-(3-Azidopropoxycarbonylamino)-2-[3-(iminoazaniumylideneamino)propoxycarbonylamino]hexanoate
• 英文别名: 6-(3-azidopropoxycarbonylamino)-2-[3-(iminoazaniumylideneamino)propoxycarbonylamino]hexanoate
• 化学式: C14H24N8O6
• 分子量: 400.39
• InChiKey: BTJRTTDXMGUTKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  28
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  168
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• [EN] POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT<br/>[FR] CONJUGUÉ POLYMÈRE POUR LA DÉLIVRANCE D'UN AGENT BIOACTIF
  申请人：POLYACTIVA PTY LTD

  公开号：WO2014134689A1

  公开（公告）日：2014-09-12

  The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from prostaglandin analogues, β-blockers and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the treatment of glaucoma.

  本发明一般涉及用于向受试者传递生物活性剂的聚合物-生物活性剂共轭物。聚合物-生物活性剂共轭物在聚合物骨架中含有三唑基团和从前列腺素类似物、β-受体阻滞剂和二者的混合物中选择的生物活性基团。本发明还涉及使用点击化学反应制备聚合物共轭物的方法，适用于制备聚合物共轭物的单体-生物活性剂共轭物，以及包含用于治疗青光眼的聚合物共轭物的药物产品。
• POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT
  申请人：POLYACTIVA PTY LTD

  公开号：US20160000929A1

  公开（公告）日：2016-01-07

  The presentinvention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from prostaglandin analogues, β-blockers and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the treatment of glaucoma.

  本发明通常涉及聚合物-生物活性剂共轭物，用于将生物活性剂传递给对象。聚合物-生物活性剂共轭物在聚合物骨架中含有三唑基团和从前列腺素类似物、β受体阻滞剂和其混合物中选择的生物活性基团。本发明还涉及使用点击化学反应制备聚合物共轭物的方法，适用于制备聚合物共轭物的单体-生物活性剂共轭物，以及包含聚合物共轭物的制药产品，用于治疗青光眼。
• Polymer conjugate for delivery of a bioactive agent
  申请人：POLYACTIVA PTY LTD

  公开号：US10113033B2

  公开（公告）日：2018-10-30

  The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety comprising prostaglandin analogues. The present invention also relates to methods for preparing the polymer conjugates using click chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the treatment of glaucoma.

  本发明总体上涉及用于向受试者输送生物活性剂的聚合物-生物活性剂共轭物。聚合物-生物活性剂共轭物的聚合物骨架中含有三唑分子，生物活性分子包括前列腺素类似物。本发明还涉及利用点击化学反应制备聚合物共轭物的方法、适用于制备聚合物共轭物的单体-生物活性剂共轭物，以及包含用于治疗青光眼的聚合物共轭物的药物产品。
• Polymer conjugate comprising a bioactive agent
  申请人：POLYACTIVA PTY LTD

  公开号：US10758626B2

  公开（公告）日：2020-09-01

  The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from quinolones, NSAIDs and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click cycloaddition chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the post-surgical care to treat or prevent infections, provide analgesia and treat inflammation.

  本发明总体上涉及用于向受试者输送生物活性剂的聚合物-生物活性剂共轭物。聚合物-生物活性剂共轭物的聚合物骨架中含有三唑分子和选自喹诺酮类、非甾体抗炎药及其混合物的生物活性分子。本发明还涉及使用单击环化化学反应制备聚合物共轭物的方法、适用于制备聚合物共轭物的单体-生物活性剂共轭物，以及包含聚合物共轭物的用于手术后治疗或预防感染、提供镇痛和治疗炎症的药物产品。
• POLYMER CONJUGATE COMPRISING A BIOACTIVE AGENT
  申请人：POLYACTIVA PTY LTD

  公开号：US20180303948A1

  公开（公告）日：2018-10-25

  The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from quinolones, NSAIDs and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click cycloaddition chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the post-surgical care to treat or prevent infections, provide analgesia and treat inflammation.