[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]amino] (2S)-2-(diaminoamino)-4-methylsulfanylbutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]amino] (2S)-2-(diaminoamino)-4-methylsulfanylbutanoate
• 化学式: C₁₄H₂₃N₉O₅S
• 分子量: 429.46
• InChiKey: AMZGCPXUYFBBGN-BIMBKFBVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  238
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• [EN] IMMUNOASSAY OF S-ADENOSYLMETHIONINE USING ANALOGS THEREOF AND PERSONALIZED THERAPEUTICS<br/>[FR] IMMUNOESSAI DE LA S-ADÉNOSYLMÉTHIONINE FAISANT APPEL À DES ANALOGUES DE CETTE DERNIÈRE ET THÉRAPEUTIQUE PERSONNALISÉE
  申请人：HUNAN SKYWORLD BIOTECHNOLOGIES CO

  公开号：WO2014146137A1

  公开（公告）日：2014-09-18

  A method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence or absence of said disease. The invention also provides methods for meauring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative ofm the health status of an individual.

  一种检测患者是否患有伴随着S-腺苷甲硫氨酸缺乏的疾病的方法，包括：识别疑似患有该疾病或有患病风险的患者；从该患者获取生物样本；使用源自S-腺苷甲硫氨酸类似物的半抗原抗体测定所述生物样本中S-腺苷甲硫氨酸的水平；并将所述生物样本中S-腺苷甲硫氨酸的水平与所述疾病的存在或不存在相关联。该发明还提供了测量SAH的方法，该方法用于确定生物液体中的甲基化指数（SAM / SAH比率），该指数表明个体的健康状况。
• Immunoassays of s-adenosylmethionine and methylation index in personalized medicine and health evaluation
  申请人：Hao Xiujuan

  公开号：US10656159B2

  公开（公告）日：2020-05-19

  The invention provides a method of detecting the presence, absence or severity of a disease in a patient wherein said disease is accompanied by decreased level of S-adenosylmethionine, or increased level of S-adenosylhomocysterine, or reduced methylation index comprising: identifying any individual or a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of SAM in said biological sample using an antibody derived from a hapten analog of SAM, SAH; and correlating the levels of SAM, SAH and MI in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for determining methylation index in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes colloidal gold test strips and homogenous enzyme immunoassays which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

  本发明提供了一种检测患者是否患有疾病或疾病严重程度的方法，其中所述疾病伴有 S-腺苷蛋氨酸水平的降低、或 S-腺苷高胞嘧啶水平的升高、或甲基化指数的降低，该方法包括确定任何疑似患有所述疾病或有可能患有所述疾病的个人或患者；从所述患者处获取生物样本；使用源自 SAM、SAH 的单体类似物的抗体确定所述生物样本中的 SAM 水平；以及将所述生物样本中的 SAM、SAH 和 MI 水平与所述疾病的存在、不存在或严重程度相关联。本发明还提供了确定生物液体中甲基化指数的方法，该指数可指示个体的健康状况。此外，本发明还包括胶体金试纸和均质酶免疫测定法，可用于测定 S-腺苷蛋氨酸和 S-腺苷高半胱氨酸。
• Immunoassay of S-adenosylmethionine in personalized medicine and health or cancer evaluation
  申请人：Hao Xiujuan

  公开号：US10663470B2

  公开（公告）日：2020-05-26

  The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes test strips which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

  本发明提供了一种检测患者是否患有疾病的方法，其中所述疾病伴随着 S-腺苷蛋氨酸水平的缺乏，该方法包括确定疑似患有所述疾病或有可能患有所述疾病的患者；从所述患者处获取生物样本；使用源自 S-腺苷蛋氨酸的合酶类似物的抗体确定所述生物样本中 S-腺苷蛋氨酸的水平；以及将所述生物样本中 S-腺苷蛋氨酸的水平与所述疾病的存在、不存在或严重程度相关联。本发明还提供了测量 SAH 的方法，SAH 可用于确定生物液体中的甲基化指数（SAM/SAH 的比率），该指数可指示个人的健康状况。此外，本发明还包括用于测定 S-腺苷蛋氨酸和 S-腺苷高半胱氨酸的试纸。
• IMMUNOASSAY OF S-ADENOSYLMETHIONINE USING ANALOGS THEREOF AND PERSONALIZED THERAPEUTICS
  申请人：Hunan Skyworld Biotechnologies Co.

  公开号：EP2968386A1

  公开（公告）日：2016-01-20
• US20140271945A1
  申请人：——

  公开号：US20140271945A1

  公开（公告）日：2014-09-18