H-Arg-Ala-Thr-Lys-Met-Leu-Gly-Ser-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Arg-Ala-Thr-Lys-Met-Leu-Gly-Ser-OH
• 英文别名: (2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoic acid
• 化学式: C₃₅H₆₆N₁₂O₁₁S
• 分子量: 863.0
• InChiKey: RYQPFEVRCPICTD-HVJWLESQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.3
• 重原子数：
  59
• 可旋转键数：
  30
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  423
• 氢给体数：
  14
• 氢受体数：
  15

文献信息

• LINKED PEPTIDE FLUOROGENIC BIOSENSORS
  申请人：Carnegie Mellon University

  公开号：EP2972355A1

  公开（公告）日：2016-01-20
• [EN] LINKED PEPTIDE FLUOROGENIC BIOSENSORS<br/>[FR] BIOCAPTEURS FLUOROGÉNIQUES À PEPTIDES LIÉS
  申请人：UNIV CARNEGIE MELLON

  公开号：WO2014142955A1

  公开（公告）日：2014-09-18

  Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen- activating peptide and a blocking peptide. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active domain of the fluorogen-activating peptide. The fluorogen-activating peptide and blocking peptide are covalently linked in certain embodiments through a peptide linker. The peptide linker may contain an amino acid sequence that is specifically recognized as a modification substrate by a cognate enzyme. The fluorogen-activating peptide and the blocking peptide at least partially disassociate when the linker is modified by a cognate enzyme, thereby allowing the fluorogen-activating peptide to bind a cognate fluorogen and modulate a fluorescence signal.