2,2-Diamino-4-oxoheptadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-Diamino-4-oxoheptadecanoic acid
• 英文别名: 2,2-diamino-4-oxoheptadecanoic acid
• 化学式: C₁₇H₃₄N₂O₃
• 分子量: 314.5
• InChiKey: XMEGEJRVVHZPEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Generation of acyl amino acids
  申请人：Modular Genetics, Inc.

  公开号：US10640799B2

  公开（公告）日：2020-05-05

  In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).

  在某些实施方案中，本发明包括用于生成酰基氨基酸的组合物和方法。在某些实施方案中，本发明提供了一种包含肽合成酶结构域的工程多肽；在某些这样的实施方案中，工程多肽仅包含单个肽合成酶结构域。在某些实施方案中，本发明提供了一种基本上不含硫酯酶结构域和/或还原酶结构域的工程肽合成酶。在某些实施方案中，本发明提供了一种包含多种不同形式酰基氨基酸的酰基氨基酸组合物。在某些此类组合物中，组合物中基本上所有的酰基氨基酸都含有相同的氨基酸分子，并在酰基分子方面有所不同。我们还描述了脂肪酸si例如长度为95%（C14，肉豆蔻酸）的群体。
• GENERATION OF ACYL AMINO ACIDS
  申请人：Modular Genetics, Inc.

  公开号：EP2970928A1

  公开（公告）日：2016-01-20
• US9970036B2
  申请人：——

  公开号：US9970036B2

  公开（公告）日：2018-05-15
• [EN] GENERATION OF ACYL AMINO ACIDS<br/>[FR] PRODUCTION D'ACIDES AMINÉS ACYLÉS
  申请人：MODULAR GENETICS INC

  公开号：WO2014144649A1

  公开（公告）日：2014-09-18

  In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).