N-(1,3-oxazol-2-yl)butane-1-sulfonamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-(1,3-oxazol-2-yl)butane-1-sulfonamide
• 化学式: C₇H₁₂N₂O₃S
• 分子量: 204.25
• InChiKey: RNJARUCWWSVXMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  80.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS
  申请人：Life Technologies Corporation

  公开号：EP2970675A2

  公开（公告）日：2016-01-20
• [EN] METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS<br/>[FR] PROCÉDÉS DE SÉLECTION DE COLORANTS POUR DES DÉTERMINATIONS DE TEMPÉRATURE DE FUSION DE PROTÉINES
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2014144360A2

  公开（公告）日：2014-09-18

  According to the present teachings, compositions, kits, and methods for protein melt analysis are provided that utilizing one or more fluorophore dyes. In some embodiments, a method comprises preparing a sample by mixing at least one protein with two or more dyes, and applying a controlled heating, while recording the fluorescence emission of the sample. The methods can be used, for example, for screening conditions for optimized protein stability, screening for ligands that bind and enhance protein stability (e.g., protein-protein interactions), screening for mutations for enhanced stability, screening crystallization conditions for protein stability, screening storage conditions for protein stability, and screening conditions in which a protein will be used (e.g., production conditions, treatment conditions, etc.) for protein stability.