6,8-Bis(2,3,5,6-tetrafluorophenoxy)tridecan-7-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 6,8-Bis(2,3,5,6-tetrafluorophenoxy)tridecan-7-one
• 英文别名: 6,8-bis(2,3,5,6-tetrafluorophenoxy)tridecan-7-one
• 化学式: C₂₅H₂₆F₈O₃
• 分子量: 526.5
• InChiKey: AZUCDZRBAPDIEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• [EN] ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] COMPOSÉS SONDES PAR ACTIVITÉ, COMPOSITIONS ET MÉTHODES D'UTILISATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2018119476A1

  公开（公告）日：2018-06-28

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

  提供用于标记半胱氨酸蛋白酶的活性探针化合物。这些化合物通过特定的靶向元素定位到蛋白酶。这些化合物还包括可检测元素，如荧光标记、放射性标记或螯合剂。在某些情况下，这些化合物还包括一种在与蛋白酶反应时释放的熄灭元素。还提供包含这些化合物的组合物和使用这些化合物的方法，例如在动物中标记蛋白酶和在动物中可视化肿瘤。
• ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20160039792A1

  公开（公告）日：2016-02-11

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

  提供用于标记半胱氨酸蛋白酶的活性探针化合物。这些化合物通过特定的靶向元素定向到蛋白酶。这些化合物还包括可检测元素，例如荧光标记、放射性标记或螯合剂。在某些情况下，这些化合物还包括一个在与蛋白酶反应后释放的熄灭元素。还提供了包含这些化合物的组合物和使用这些化合物的方法，例如在动物中标记蛋白酶和可视化动物中的肿瘤。
• Activity-based probe compounds, compositions, and methods of use
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US10100037B2

  公开（公告）日：2018-10-16

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

  提供了用于标记半胱氨酸蛋白酶的基于活性的探针化合物。这些化合物通过特定的靶向元件靶向蛋白酶。化合物还包括可检测元素，如荧光标签、放射性标签或螯合剂。在某些情况下，化合物还包括一种淬灭元素，在与蛋白酶反应时释放出来。此外，还提供了包含这些化合物的组合物和使用这些化合物的方法，例如标记动物体内的蛋白酶和观察动物体内的肿瘤。
• [EN] ACTIVITY-BASED PROBE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] COMPOSÉS DE SONDE BASÉE SUR L'ACTIVITÉ, COMPOSITIONS ET MÉTHODES D'UTILISATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2014145257A2

  公开（公告）日：2014-09-18

  Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.