[EN] BORON-CONTAINING DIACYLHYDRAZINES<br/>[FR] DIACYLHYDRAZINES CONTENANT DU BORE
申请人:INTREXON CORP
公开号:WO2014144380A1
公开(公告)日:2014-09-18
The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.