H-Pyr-His-Pro-Me

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Pyr-His-Pro-Me
• 英文别名: (2S)-N-[(2S)-1-[(2S)-2-acetylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
• 化学式: C₁₇H₂₃N₅O₄
• 分子量: 361.4
• InChiKey: ZDIIHYDHPPBXDU-IHRRRGAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Wound healing using topical systems and methods
  申请人：Transdermal Biotechnology, Inc.

  公开号：US10034944B2

  公开（公告）日：2018-07-31

  The present invention generally relates to compositions and methods for topical or transdermal delivery and treatment of wounds and/or promoting wound healing. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., wounded skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

  本发明一般涉及局部或透皮给药和治疗伤口和/或促进伤口愈合的组合物和方法。在某些情况下，组合物可包括一氧化氮和/或肽，如促甲状腺激素释放激素（TRH）和/或促性腺激素释放激素（GnRH）。一氧化氮和/或肽可存在于包含卵磷脂（如磷脂酰胆碱）的第一阶段中。在某些实施方案中，卵磷脂存在于脂质体、胶束或其他含有一氧化氮、肽或两者的结构中。本发明的组合物可以是凝胶、膏霜、乳液、软膏、溶液、固体 "棒 "等形式，可以涂抹或喷洒在皮肤上，例如受伤的皮肤上。本发明的其他方面一般涉及制造或使用这种组合物的方法、推广这种组合物的方法、包括这种组合物的成套工具或类似物。
• Brain and neural treatments comprising peptides and other compositions
  申请人：Transdermal Biotechnology, Inc.

  公开号：US10034914B2

  公开（公告）日：2018-07-31

  The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth, muscle repair, improved muscular and neuromuscular control, and treatments for neuromuscular and neurological disorders, including brain disorders. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptides may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide and/or peptide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto a location where muscle growth, muscle repair, or improved muscular and neuromuscular control is desired, or on another suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

  本发明一般涉及用于治疗需要肌肉生长、肌肉修复、改善肌肉和神经肌肉控制的受试者的组合物和方法，以及神经肌肉和神经系统疾病（包括脑部疾病）的治疗方法。在某些情况下，组合物可包括一氧化氮和/或肽，如促甲状腺激素释放激素（TRH）和/或促性腺激素释放激素（GnRH）。一氧化氮和/或肽可存在于包含卵磷脂（如磷脂酰胆碱）的第一阶段中。在某些实施方案中，卵磷脂存在于含有一氧化氮和/或肽的脂质体、胶束或其他结构中。本发明的组合物可以是凝胶、膏霜、乳液、软膏、溶液、固体 "棒 "等形式，可以涂抹或喷洒在皮肤上，例如，涂抹在希望增长肌肉、修复肌肉或改善肌肉和神经肌肉控制的位置上，或涂抹在皮肤的其他合适部位上。本发明的其他方面一般涉及制造或使用此类组合物的方法、推广此类组合物的方法、包括此类组合物的试剂盒或类似物。
• US20140271731A1
  申请人：——

  公开号：US20140271731A1

  公开（公告）日：2014-09-18
• US20140271937A1
  申请人：——

  公开号：US20140271937A1

  公开（公告）日：2014-09-18
• US20140271938A1
  申请人：——

  公开号：US20140271938A1

  公开（公告）日：2014-09-18