3-[4-[1-[3-[3-[butyl(methyl)amino]propylamino]-3-oxopropyl]piperidin-4-yl]piperidin-1-yl]-N-methylpropanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[4-[1-[3-[3-[butyl(methyl)amino]propylamino]-3-oxopropyl]piperidin-4-yl]piperidin-1-yl]-N-methylpropanamide
• 化学式: C₂₅H₄₉N₅O₂
• 分子量: 451.7
• InChiKey: LHTCZPLNKZGQCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  67.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMINE FUNCTIONAL POLYAMIDES
  申请人：GENZYME CORPORATION

  公开号：US20160208046A1

  公开（公告）日：2016-07-21

  Amine functional polyamides comprise amine and ammonium groups along the polymer chain. Amine functional polyamides can be used as pharmaceutical agents and in pharmaceutical compositions. The amine functional polyamides are particularly useful in the treatment or prevention of mucositis and infection, specifically oral mucositis, surgical site infection, and lung infection associated with cystic fibrosis.

  氨基官能团聚酰胺是由氨基和铵基团组成的高分子链。氨基官能团聚酰胺可用作制药剂和制药组合物。氨基官能团聚酰胺在治疗或预防粘膜炎和感染方面特别有用，尤其是口腔粘膜炎、手术部位感染和与囊性纤维化相关的肺部感染。
• US20140271526A1
  申请人：——

  公开号：US20140271526A1

  公开（公告）日：2014-09-18
• US20140275469A1
  申请人：——

  公开号：US20140275469A1

  公开（公告）日：2014-09-18
• Multi-dose Compositions Containing an Antimicrobial Polyamide or Octenidine Preservative
  申请人：MERIAL INC.

  公开号：US20170296577A1

  公开（公告）日：2017-10-19

  The present invention relates to non-mercurial preservatives, including antimicrobial polyamide polymers and octenidine, and to methods of use thereof to produce preservative-containing multi-dose formulations. The preservative-containing multi-dose formulations exhibit resistance to one or more contaminating microorganisms, and have advantageous properties with respect to long term stability of biological and small molecule active ingredients.
• US9326994B2
  申请人：——

  公开号：US9326994B2

  公开（公告）日：2016-05-03