N-[3-hydroxy-1-[(2R,3S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypent-4-en-2-yl]formamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-[3-hydroxy-1-[(2R,3S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypent-4-en-2-yl]formamide
• 化学式: C₁₂H₂₁NO₈
• 分子量: 307.3
• InChiKey: SMEXQKWYCIBXMS-WBRCOJFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  149
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• [EN] COMPOUNDS AND METHODS RELATING TO TESTING FOR LYSOSOMAL STORAGE DISORDERS<br/>[FR] COMPOSÉS ET MÉTHODES RELATIFS À UN TEST DE TROUBLES DE STOCKAGE LYSOSOMIAL
  申请人：PERKINELMER HEALTH SCI INC

  公开号：WO2014145418A1

  公开（公告）日：2014-09-18

  Substrates are provided that include compounds suitable for detecting the activity of an enzyme such as a lysosomal storage enzyme where the substrates include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are methods for using substrates for detecting enzymatic activity using the inventive substrates.