Ethyl 5-cyano-1-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]pyrrole-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Ethyl 5-cyano-1-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]pyrrole-2-carboxylate
• 英文别名: ethyl 5-cyano-1-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]pyrrole-2-carboxylate
• 化学式: C₁₆H₂₃N₃O₄
• 分子量: 321.37
• InChiKey: YDBLAOQEGUPBEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] HYBRID NECROPTOSIS INHIBITORS<br/>[FR] INHIBITEURS HYBRIDES DE LA NÉCROPTOSE
  申请人：HARVARD COLLEGE

  公开号：WO2014145022A1

  公开（公告）日：2014-09-18

  The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.

  本发明涉及杂环化合物（例如，由式（I）描述的化合物）及其药学上可接受的盐。该发明还涉及包括这些化合物的药物组合物，以及它们在治疗可能出现大量坏死相关凋亡的疾病中的用途。本文描述的杂环化合物还可以实现对RIP1和/或RIP3的改进活性和选择性。
• HYBRID NECROPTOSIS INHIBITORS
  申请人：President and Fellows of Harvard College

  公开号：US20140323489A1

  公开（公告）日：2014-10-30

  The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.
• US9725452B2
  申请人：——

  公开号：US9725452B2

  公开（公告）日：2017-08-08