2-Methyl-5-oxo-5-[2-[2-(2-oxopropoxy)ethoxy]ethylamino]pentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Methyl-5-oxo-5-[2-[2-(2-oxopropoxy)ethoxy]ethylamino]pentanoic acid
• 英文别名: 2-methyl-5-oxo-5-[2-[2-(2-oxopropoxy)ethoxy]ethylamino]pentanoic acid
• 化学式: C₁₃H₂₃NO₆
• 分子量: 289.32
• InChiKey: IFDSYCWUHCIBNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• US8841249B2
  申请人：——

  公开号：US8841249B2

  公开（公告）日：2014-09-23
• [EN] RADIOPHARMACEUTICAL CONJUGATES TARGETING GUANYLYL CYCLASE C, AND COMPOSITIONS AND USES THEREOF<br/>[FR] CONJUGUÉS RADIOPHARMACEUTIQUES CIBLANT LA GUANYLYLE CYCLASE C, ET COMPOSITIONS ET UTILISATIONS DE CEUX-CI
  申请人：[en]RAYZEBIO, INC.

  公开号：WO2022115799A1

  公开（公告）日：2022-06-02

  Provided herein are radiopharmaceutical conjugate compositions and uses thereof. In one aspect, provided herein are conjugates that comprise a GCC binding peptide, a metal chelator configured to bind with a radionuclide, a linker that attaches the GCC binding peptide with the metal chelator, and optionally a radionuclide. Also provided herein are conjugates that have improved elimination profile and plasma stability that are suitable for radiopharmaceutical applications and methods of using the same in treating and/or diagnosing diseases such as cancer.