2-amino-5-(diaminomethylideneamino)-N-(2-methylprop-2-enyl)pentanamide;hydron;chloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-5-(diaminomethylideneamino)-N-(2-methylprop-2-enyl)pentanamide;hydron;chloride
• 化学式: C10H22ClN5O
• 分子量: 263.77
• InChiKey: LXPGWCDTWQRAAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.82
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• SEQUESTRANTS OF ADVANCED GLYCATION END PRODUCT (AGE) PRECURSORS
  申请人：GENZYME CORPORATION

  公开号：US20160024233A1

  公开（公告）日：2016-01-28

  Sequestrants of AGE precursors comprise amines separated by 2, 3 or 4 carbons. Sequestrants of AGE precursors can be used as pharmaceutical agents and in pharmaceutical compositions. The sequestrants of AGE precursors are particularly useful binding AGE precursors and dietary dicarbonyls in mammals in the gastrointestinal tract for the treatment of ailments such as diabetic nephropathy, chronic renal disease, atherosclerosis, stroke, cataracts, and Alzheimer's disease.

  AGE前体的螯合剂包括间隔2、3或4个碳的胺类物质。AGE前体的螯合剂可用作药物剂和药物配方。AGE前体的螯合剂特别有用于在哺乳动物的胃肠道中结合AGE前体和饮食中的二羧基化合物，用于治疗糖尿病肾病、慢性肾脏疾病、动脉硬化、中风、白内障和阿尔茨海默病等疾病。
• NOVEL COMPOUND, POLYMER PREPARED FROM THE COMPOUND, AND COMPOSITION COMPRISING THE POLYMER
  申请人：POLA CHEMICAL INDUSTRIES INC.

  公开号：EP1156031B1

  公开（公告）日：2008-09-17
• US6703468B1
  申请人：——

  公开号：US6703468B1

  公开（公告）日：2004-03-09
• [EN] SEQUESTRANTS OF ADVANCED GLYCATION END PRODUCT (AGE) PRECURSORS<br/>[FR] AGENTS SÉQUESTRANTS DE PRÉCURSEURS DE PRODUITS TERMINAUX DE GLYCATION AVANCÉE (AGE)
  申请人：GENZYME CORP

  公开号：WO2014150873A1

  公开（公告）日：2014-09-25

  Sequestrants of AGE precursors comprise amines separated by 2, 3 or 4 carbons. Sequestrants of AGE precursors can be used as pharmaceutical agents and in pharmaceutical compositions. The sequestrants of AGE precursors are particularly useful binding AGE precursors and dietary dicarbonyls in mammals in the gastrointestinal tract for the treatment of ailments such as diabetic nephropathy, chronic renal disease, atherosclerosis, stroke, cataracts, and Alzheimer's disease.