(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(5-thiophen-2-ylpentoxy)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(5-thiophen-2-ylpentoxy)oxane-3,4,5-triol
• 化学式: C₁₅H₂₄O₆S
• 分子量: 332.4
• InChiKey: VODTYBSUVNHNJI-FQKPHLNHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  128
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Thiosaccharide mucolytic agents
  申请人：The Regents of the University of California

  公开号：US11021506B2

  公开（公告）日：2021-06-01

  There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

  除其他外，还提供了用于降低有需要的受试者的粘液弹性或粘液粘度的方法，这些方法包括向受试者施用有效量的硫糖粘液溶解剂，以及用于这些方法的化合物和药物组合物。
• THIOSACCHARIDE MUCOLYTIC AGENTS
  申请人：The Regents of the University of California

  公开号：EP2968215A2

  公开（公告）日：2016-01-20
• THIOSCCHARIDE MUCOLYTIC AGENTS
  申请人：The Regents of the University of California

  公开号：US20200102340A1

  公开（公告）日：2020-04-02

  There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.
• [EN] THIOSACCHARIDE MUCOLYTIC AGENTS<br/>[FR] AGENTS MUCOLYTIQUES THIOSACCHARIDIQUES
  申请人：UNIV CALIFORNIA CORP

  公开号：WO2014153009A2

  公开（公告）日：2014-09-25

  There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.