2,2,6-trimethyl-4-(5-nitropyridin-2-yl)-3H-pyran-6-carboxylic acid

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 2,2,6-trimethyl-4-(5-nitropyridin-2-yl)-3H-pyran-6-carboxylic acid
• 化学式: C14H16N2O5
• 分子量: 292.29
• InChiKey: UIRKFSADABXBDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS C-FMS KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDINE SUBSTITUÉS UTILES EN TANT QU'INHIBITEURS DE KINASE C-FMS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014151258A1

  公开（公告）日：2014-09-25

  The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.

  本发明涉及取代吡啶衍生物，含有该衍生物的药物组合物，以及在治疗由c-fms激酶介导的疾病中使用该衍生物。本发明还涉及一种制备所述取代吡啶衍生物的方法。
• SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS C-FMS KINASE INHIBITORS
  申请人：CHEN Jie

  公开号：US20160016942A1

  公开（公告）日：2016-01-21

  The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.

  本发明涉及取代的吡啶衍生物、含有该衍生物的药物组合物以及使用该衍生物治疗由c-fms激酶介导的疾病的方法。本发明还涉及一种制备该取代的吡啶衍生物的方法。
• Substituted pyridine derivatives useful as c-fms kinase inhibitors
  申请人：Janssen Pharmaceutica NV

  公开号：US10071991B2

  公开（公告）日：2018-09-11

  The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.

  本发明涉及取代的吡啶衍生物、含有所述衍生物的药物组合物以及所述衍生物在治疗由 c-fms 激酶介导的疾病中的用途。本发明进一步涉及制备所述取代的吡啶衍生物的工艺。
• Substituted pyridine derivatives useful as C-FMS kinase inhibitors
  申请人：Janssen Pharmaceutica NV

  公开号：US10800764B2

  公开（公告）日：2020-10-13

  The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.

  本发明涉及取代的吡啶衍生物、含有所述衍生物的药物组合物以及所述衍生物在治疗由 c-fms 激酶介导的疾病中的用途。本发明进一步涉及一种制备所述取代的吡啶衍生物的工艺。
• Substituted Pyridine Derivatives Useful As C-FMS Kinase Inhibitors
  申请人：Janssen Pharmaceutica NV

  公开号：US20180346454A1

  公开（公告）日：2018-12-06

  The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.