(2S)-2-[(2-oxo-3H-indol-1-yl)amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[(2-oxo-3H-indol-1-yl)amino]propanoic acid
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.22
• InChiKey: JFQMVWDDPNWXAN-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HDL-associated protein extraction and detection
  申请人：Cleveland HeartLab, Inc.

  公开号：US10466260B2

  公开（公告）日：2019-11-05

  Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.

  本文提供了从样品（如血浆或血清样品）中提取和检测至少一种 HDL 相关蛋白（如载脂蛋白 ApoA1）的组合物、系统和方法。在某些实施方案中，将强有机酸和亲水性有机溶剂与样品混合；离心后，将上清液转移到第二个容器中，在此与非极性有机溶剂混合；离心后，将下层水层转移到第三个容器中；然后将转移的水层中的至少一部分进行检测试验，从而检测出至少一种 HDL 相关蛋白。
• UNIVERSAL OR NORMALIZED ANTIBODY FRAMEWORKS FOR IMPROVED FUNCTIONALITY AND MANUFACTURABILITY
  申请人：Ventana Medical Systems, Inc.

  公开号：EP3802588A1

  公开（公告）日：2021-04-14
• FECAL-DERIVED STERILE POSTBIOTIC COMPOSITION AND METHOD THEREFOR
  申请人：Thaena Inc.

  公开号：EP4045069A1

  公开（公告）日：2022-08-24
• HDL-ASSOCIATED PROTEIN EXTRACTION AND DETECTION
  申请人：Cleveland HeartLab, Inc.

  公开号：US20160084856A1

  公开（公告）日：2016-03-24

  Provided herein are compositions, systems, and methods for extracting and detecting at least one HDL-associated protein (e.g., ApoA1) from a sample (e.g., plasma or serum sample). In certain embodiments, a strong organic acid and hydrophilic organic solvent are mixed with the sample; after centrifugation, the supernatant is transferred to a second container where it is mixed with a non-polar organic solvent; after centrifugation, the lower aqueous layer is transferred to a third container; and then at least a portion of the transferred aqueous layer is subjected to a detection assay such that at least one HDL-associated protein is detected.
• BIOMARKERS OF METHYLGLYOXAL AND RELATED METHODS THEREOF
  申请人：THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

  公开号：US20190137505A1

  公开（公告）日：2019-05-09

  The present invention relates to methods and biomarkers for detection, characterization and treatment of conditions associated with methylglyoxal (MG) in biological samples. In particular, the present invention provides compositions and methods for determining diabetic complication onset in a patient through detecting a o-phenylenediamine derivatized MG (2MQ) product as indicative of the presence of MG, impaired fibrinolysis in a patient through detecting a MG modified plasminogen (Pg) product as indicative of impaired fibrinolysis, and the efficacy of metformin (MF) treatment in a patient through detecting IMZ as indicative of a MF/MG product.