(2E)-N-[2-(diethylamino)ethyl]-2-hydroxyiminoacetamide;hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2E)-N-[2-(diethylamino)ethyl]-2-hydroxyiminoacetamide;hydrochloride
• 化学式: C8H18ClN3O2
• 分子量: 223.7
• InChiKey: VQVZHRWARHXTFH-HCUGZAAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.33
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  64.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Oximes For Treatment Of Peripheral And Central Nervous System Exposure To Acetyl Cholinesterase Inhibitors
  申请人：MCHARDY Stanton F.

  公开号：US20130035351A1

  公开（公告）日：2013-02-07

  The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.
• OXIMES FOR TREATMENT OF PERIPHERAL AND CENTRAL NERVOUS SYSTEM EXPOSURE TO ACETYL CHOLINESTERASE INHIBITORS
  申请人：McHardy Stanton F.

  公开号：US20140066421A1

  公开（公告）日：2014-03-06

  The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.
• Oximes For Treatment Of Peripheral And Central Nervous System Exposure to Acetyl Cholinesterase Inhibitors
  申请人：Southwest Research Institute

  公开号：US20150005328A1

  公开（公告）日：2015-01-01

  The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.
• US8653108B1
  申请人：——

  公开号：US8653108B1

  公开（公告）日：2014-02-18
• US8772345B2
  申请人：——

  公开号：US8772345B2

  公开（公告）日：2014-07-08