N-甲酰基-2-羟基苯甲酰胺 | 67936-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-甲酰基-2-羟基苯甲酰胺
• 英文名称: N-formyl-2-hydroxybenzamide
• 英文别名: N-formylsalicylamide；formyl-salicyloyl-amine；N-Formyl-salicylamid；Formyl-salicyloyl-amin；N-Formyl-salicylamid；N-Formylsalicylamid
• CAS: 67936-24-7
• 化学式: C₈H₇NO₃
• mdl: MFCD10568307
• 分子量: 165.148
• InChiKey: GNIFQFSQXIJJSP-UHFFFAOYSA-N

物化性质

• 熔点：
  162 °C (decomp)
• 密度：
  1.315±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-甲酰基-2-羟基苯甲酰胺 、 甲乙酐 在 吡啶 作用下， 以 氯仿 为溶剂， 以75%的产率得到2-formyloxy-3-formyl-2,3-dihydro-1,3-benzoxazin-4-one
  参考文献：
  名称：

  Treppendahl, Svend; Jakobsen, Palle, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1983, vol. 37, # 10, p. 953 - 955

  摘要：

  DOI：
• 作为产物：
  描述：

  水杨酰胺 在 对甲苯磺酸 、 臭氧 作用下， 以 氯仿 为溶剂， 生成 N-甲酰基-2-羟基苯甲酰胺
  参考文献：
  名称：

  3,4-二氢-4-氧代-2 H -1,3-苯并恶嗪-羧酸

  摘要：

  描述了几种3,4-二氢-4-氧代-2 H -1,3-苯并恶嗪-羧酸的合成。酸是由碳酸氢盐水解其相应的酯产生的，这些酯是通过水杨酰胺与各种醛和酮的缩合反应制得的。某些含有邻羧基官能团的芳族醛和酮的使用导致异吲哚并苯并恶嗪结构。

  DOI：

  10.1039/j39710000146

文献信息

• An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)
  作者：M. Sambaiah、Ramakrishna Gudipati、K. Shiva Kumar、Satyanarayana Yennam、Manoranjan Behera

  DOI：10.1016/j.tetlet.2015.12.046

  日期：2016.1

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.
• Inhibitory effect of metalloporphyrins in conjunction with cholesterol on hepatic phospholipase A2 activityin vivo in rats
  作者：Ramesh Chandra、Manisha Tiwari、Ritu Aneja、Sujata K. Dass、Archana Sharma

  DOI：10.1007/bf02883744

  日期：2000.7

  We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin (CrPP) on phospholipase A(2) (PLA(2)) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition of PLA(2) activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA(2) activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to membrane lysis.
• The Reaction of Salicylamide with Triethyl Orthoformate.
  作者：Svend Treppendahl、Palle Jakobsen、Claudine Narbonne、Toshiaki Nishida、Curt R. Enzell

  DOI：10.3891/acta.chem.scand.35b-0465

  日期：——
• TREPPENDAHL, S.;JAKOBSEN, P., ACTA CHEM. SCAND., 1981, 35, N 6, 465-466
  作者：TREPPENDAHL, S.、JAKOBSEN, P.

  DOI：——

  日期：——
• TREPPENDAHL, S.;JAKOBSEN, P., ACTA CHEM. SCAND., 1983, 37, N 10, 953-955
  作者：TREPPENDAHL, S.、JAKOBSEN, P.

  DOI：——

  日期：——