N¹,N¹-dimethyl-N²-salicyloylformamidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹,N¹-dimethyl-N²-salicyloylformamidine
• 英文别名: N-[1-Dimethylaminomethylidene]-2-hydroxybenzamide；N-(dimethylaminomethylidene)-2-hydroxybenzamide
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: HRSJTXQRPZEJRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N¹,N¹-dimethyl-N²-salicyloylformamidine 在 1-丙基磷酸酐 作用下， 以 乙酸乙酯 为溶剂， 反应 12.0h， 以75%的产率得到N-甲酰基-2-羟基苯甲酰胺
  参考文献：
  名称：

  An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)

  摘要：

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.046
• 作为产物：
  描述：

  N,N-二甲基甲酰胺二甲基缩醛 、 水杨酰胺 以 甲苯 为溶剂， 反应 12.0h， 生成 N¹,N¹-dimethyl-N²-salicyloylformamidine
  参考文献：
  名称：

  An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)

  摘要：

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.046

文献信息

• Kostka, Krzysztof; Kotynski, Andrzej, Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 83, # 1-4, p. 215 - 222
  作者：Kostka, Krzysztof、Kotynski, Andrzej

  DOI：——

  日期：——
• An efficient method for the preparation of N-formyl-imide via amidine using propylphosphonic anhydride (T3P®)
  作者：M. Sambaiah、Ramakrishna Gudipati、K. Shiva Kumar、Satyanarayana Yennam、Manoranjan Behera

  DOI：10.1016/j.tetlet.2015.12.046

  日期：2016.1

  An efficient method for the preparation of N-formyl imide via amidine using propylphosphonic anhydride (T3P (R)) has been described. Using this method many aryl, hetero aryl, alkyl as well as amino acid imides were synthesized in high yields. (C) 2015 Elsevier Ltd. All rights reserved.