1-phenethyl-3-phenethylamino-pyrrole-2,5-dione | 40259-22-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-phenethyl-3-phenethylamino-pyrrole-2,5-dione
• 英文别名: 1-phenethyl-3-(phenethylamino)-1H-pyrrole-2,5-dione；1-(2-phenylethyl)-3-(2-phenylethylamino)pyrrole-2,5-dione
• CAS: 40259-22-1
• 化学式: C₂₀H₂₀N₂O₂
• 分子量: 320.391
• InChiKey: RGABADSGWBLGAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-phenethyl-3-phenethylamino-pyrrole-2,5-dione 、 4-dimethylaminophenylamine dihydrochloride 以 甲醇 为溶剂， 反应 1.0h， 以41%的产率得到3-((4-(dimethylamino)phenyl)amino)-1-phenethyl-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  2-氨基吡咯-2，5-二酮2.用芳基胺对1-烷基-3-烷基氨基吡咯-2，5-二酮中的烷基氨基进行乙烯基亲核取代

  摘要：

  In vinyl nucleophilic substitution (S(N)vin) with the hydrochlorides or 4-toluenesulfonates of primary arylamines 1-alkyl-3-alkylaminopyrrole-2,5-diones form the corresponding 1-alkyl-3-arylaminopyrrole- 2,5-diones, which are also produced in situ from the corresponding arylaminofumarates and primary alkylamines.

  DOI：

  10.1007/s10593-008-0071-z

文献信息

• Microwave-assisted DABCO-promoted regioselective [3 + 3] tandem cyclization: synthesis of pyrrolo[3,4-<i>b</i>]pyridine-4-ones from trifluoromethyl-alkynyl esters and α-aminomaleimide
  作者：Qi Yang、Shuntao Huang、Lu Yin、Zhuoyu Wang、Xuebing Chen、Chao Huang

  DOI：10.1039/d3ob01015e

  日期：——

  DABCO-promoted strategy for the regioselective synthesis of pyrrolo[3,4-b]pyridine-4-one derivatives has been developed from the [3 + 3] annulation of α-aminomaleimide with substituted ethyl 2-butynoate. The characteristic features of this methodology include operational simplicity, high regioselectivity, metal-free reaction conditions, and short reaction times. The potential utility of these methods

  一种微波辅助 DABCO 促进的吡咯并[3,4- b ]吡啶-4-酮衍生物区域选择性合成策略，由 α-氨基马来酰亚胺与取代的 2-丁酸乙酯的 [3 + 3] 成环反应开发而成。该方法的特点包括操作简单、区域选择性高、无金属反应条件和反应时间短。强调了这些方法在生物化学和医学科学应用中的潜在效用。
• 2-Aminopyrrole-2,5-diones 2. Vinyl nucleophilic substitution of the alkylamino group in 1-alkyl-3-alkylaminopyrrole-2,5-diones by arylamines
  作者：S. V. Chepyshev、Yu. N. Chepysheva、A. B. Ryabitskii、A. V. Prosyanik

  DOI：10.1007/s10593-008-0071-z

  日期：2008.5

  In vinyl nucleophilic substitution (S(N)vin) with the hydrochlorides or 4-toluenesulfonates of primary arylamines 1-alkyl-3-alkylaminopyrrole-2,5-diones form the corresponding 1-alkyl-3-arylaminopyrrole- 2,5-diones, which are also produced in situ from the corresponding arylaminofumarates and primary alkylamines.