2,3-bis[[(E)-octadec-9-enoyl]oxy]propyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-bis[[(E)-octadec-9-enoyl]oxy]propyl-trimethylazanium
• 化学式: C42H80NO4+
• 分子量: 663.1
• InChiKey: KWVJHCQQUFDPLU-DQPVQCHKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.1
• 重原子数：
  47
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOSITIONS AND METHODS FOR STABILIZING LIPID BASED ADJUVANT FORMULATIONS USING GLYCOLIPIDS
  申请人：Statens Serum Institut

  公开号：EP1765289B1

  公开（公告）日：2008-09-03
• USE OF TARGETED CROSS-LINKED NANOPARTICLES FOR IN VIVO GENE DELIVERY
  申请人：Bednarski Mark D.

  公开号：US20090048201A1

  公开（公告）日：2009-02-19

  The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.