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2,3,4,5-tetrabromobiphenyl | 115245-09-5

中文名称
——
中文别名
——
英文名称
2,3,4,5-tetrabromobiphenyl
英文别名
1,2,3,4-tetrabromo-5-phenylbenzene
2,3,4,5-tetrabromobiphenyl化学式
CAS
115245-09-5
化学式
C12H6Br4
mdl
——
分子量
469.796
InChiKey
NYSAPLQZKHQBSO-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    6.3
  • 重原子数:
    16
  • 可旋转键数:
    1
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    0
  • 氢给体数:
    0
  • 氢受体数:
    0

ADMET

代谢
多溴联苯(PBBs)可以通过口服、吸入和皮肤途径被吸收。由于其亲脂性,特别是高度溴化的同类物,PBBs倾向于在富含脂质的组织中积累,如肝脏、脂肪、皮肤和母乳。某些PBB化合物通过由苯巴比妥诱导类型的细胞色素P-450催化的微囊膜单加氧酶系统进行代谢。代谢速率可能取决于溴取代模式。低溴含量的多溴联苯同类物转化为主要在尿液中排出的羟基衍生物。高度溴化的同类物要么被保留,要么不变地在粪便中排出。(L628)
PBBs can be absorbed via oral, inhalation, and dermal routes. Due to their lipophilic nature, PBBs, especially the highly brominated congeners, tend to accumulate in lipid-rich tissues such as the liver, adipose, skin, and breast milk. Certain PBB compounds are metabolized by the microsomal monooxygenase system catalyzed by cytochrome P-450 of the type induced by phenobarbital. The rate of metabolism may depends on the bromine substitution pattern. PBB congeners of low bromine content are transformed into hydroxylated derivatives that are predominately eliminated in the urine. Highly brominated congeners are either retained or excreted unchanged in the feces. (L628)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
  • 毒性总结
多氯联苯(PBBs)的毒性机制因具体同系物而异。主要的相互作用被认为是涉及芳基烃受体(AhR)。PBBs与AhR结合并激活它,进而启动一系列基因的转录上调,影响生化途径和内分泌途径、细胞周期调节、形态发生、氧化应激反应以及各种其他过程。这导致PBBs特有的多种毒性反应。一些已知的诱导基因包括细胞色素P-450依赖性单加氧酶CYP1A1和CYP1A2。
The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR). PBBs bind to and activate the AhR, which in turn initiates the transcriptional upregulation of a number of genes, affecting biochemical and endocrine pathways, cell cycle regulation, morphogenesis, oxidative stress response, and various other processes. This results in the numerous toxic responses characteristic of PBBs. Some of the known induced genes include the cytochrome P-450-dependent monooxygenases CYP1A1 and CYP1A2. (L628)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
  • 致癌物分类
2A,可能对人类致癌。(L135)
2A, probably carcinogenic to humans. (L135)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
  • 健康影响
PBB暴露可能会导致体重减轻、皮肤问题(如痤疮)、神经和免疫系统的影响,以及对肝脏、肾脏和甲状腺的影响。
PBB exposure may cause weight loss, skin disorders (such as acne), nervous and immune systems effects, and effects on the liver, kidneys, and thyroid gland. (L628)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
  • 暴露途径
口服(L628);吸入(L628);皮肤给药(L628)
Oral (L628) ; inhalation (L628) ; dermal (L628)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
  • 症状
PBB暴露的症状可能包括恶心、腹痛、食欲不振、关节痛、疲劳和虚弱。
Symptoms of PBB exposure may include nausea, abdominal pain, loss of appetite, joint pain, fatigue, and weakness. (L629)
来源:Toxin and Toxin Target Database (T3DB)

上下游信息

反应信息

  • 作为反应物:
    描述:
    三苯基氯硅烷2,3,4,5-tetrabromobiphenyl正丁基锂 作用下, 以 四氢呋喃正己烷 为溶剂, 反应 0.5h, 以85%的产率得到三(苯基)-(4-苯基苯基)硅烷
    参考文献:
    名称:
    一种四苯基硅烷衍生物及其制备方法
    摘要:
    本申请属于有机化学合成技术领域,特别是涉及一种四苯基硅烷衍生物及其制备方法。现有的四苯基硅烷及其衍生物反应复杂,产率低,后处理复杂。本申请提供了一种四苯基硅烷衍生物,所述衍生物通式为:其中,R1为氢,烷基,卤素,氨基,氰基,硝基,羧基,芳香化合物及其衍生物或者稠环。反应简单易操作,反应安全,产率高,后处理简单,废水少,更环保。
    公开号:
    CN114213444A
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文献信息

  • [EN] HYDROSILYLATION REACTION CURABLE COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE<br/>[FR] COMPOSITIONS DURCISSABLES PAR UNE RÉACTION D'HYDROSILYLATION ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
    申请人:DOW CORNING
    公开号:WO2013000788A1
    公开(公告)日:2013-01-03
    A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a platinum-ligand complex that can be prepared by reacting a platinum precursor and a ligand.
    一种组合物包含(A)氢硅烷化反应催化剂和(B)一种脂肪族不饱和化合物,每分子平均含有一个或多个能够进行氢硅烷化反应的脂肪族不饱和有机基团。该组合物能够通过氢硅烷化反应反应形成反应产物,如硅烷、树胶、凝胶、橡胶或树脂。成分(A)包含一种铂配体络合物,可通过反应铂前体和配体制备。
  • [EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
    申请人:DOW SILICONES CORP
    公开号:WO2020142474A1
    公开(公告)日:2020-07-09
    A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.
    提供了一种制备丙烯酸酯官能化分支有机硅化合物(“化合物”)的方法,包括在催化剂存在下,使(A)分支有机硅化合物和(B)丙烯酸酯化合物发生反应,其中组分(A)具有一般式X-Si(R1)3,其中X包括卤素官能基,每个R1从R和–OSi(R4)3中选择,但至少一个R1为–OSi(R4)3;每个R4从R、–OSi(R5)3和–[OSiR2]mOSiR3中选择;每个R5从R、–OSi(R6)3和–[OSiR2]mOSiR3中选择;每个R6从R和–[OSiR2]mOSiR3中选择;每个R是独立选择的烃基;且0≤m≤100;但至少一个R4、R5和R6为–[OSiR2]mOSiR3。还提供了通过该方法制备的化合物,包括化合物和第二化合物的反应产物的共聚物,形成共聚物的方法,以及包含共聚物的组合物。
  • METALLIC CROSSLINKING COAGENT, PREPARATION METHODS THEREOF, AND RESIN COMPOSITION COMPRISING THE SAME
    申请人:KUO CHING CHEMICAL CO., LTD.
    公开号:US20160326196A1
    公开(公告)日:2016-11-10
    Provided are a metallic crosslinking coagent, preparation methods thereof, and a resin composition comprising the metallic crosslinking coagent. With the active-hydrogen containing organic phosphorus compound group and metallophilic acrylate group, the metallic crosslinking coagent provides both stabilizer and flame-retardant effects, enhances the crosslinking efficiency of the resin composition, and improves the compatibility between flame retardant and the polymer. Accordingly, the metallic crosslinking coagent is effective to improve the mechanical properties of the application material and to develop a safe and environmentally friendly flame retardant material.
    提供了一种金属交联交联剂,其制备方法,以及包含该金属交联交联剂的树脂组合物。金属交联交联剂具有活性氢含有机磷化合物基团和金属亲和丙烯酸酯基团,提供了稳定剂和阻燃效果,增强了树脂组合物的交联效率,并改善了阻燃剂与聚合物之间的相容性。因此,金属交联交联剂有效地提高了应用材料的机械性能,并开发了一种安全和环保的阻燃材料。
  • Hydrosilylation Reaction Catalysts and Curable Compositions and Methods for Their Preparation and Use
    申请人:Dow Corning Corporation
    公开号:US20140296468A1
    公开(公告)日:2014-10-02
    A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains an iron-organosilicon ligand complex that can be prepared by reacting an iron carbonyl compound and an organosilicon ligand.
    一种组合物包含(A)一个氢硅烷基化反应催化剂和(B)一种脂肪族不饱和化合物,每个分子平均含有一个或多个能够进行氢硅烷基化反应的脂肪族不饱和有机基团。该组合物能够通过氢硅烷基化反应反应形成反应产物,如硅烷、树脂、凝胶、橡胶或树脂。成分(A)包含一种铁-有机硅配体络合物,可通过反应铁羰基化合物和有机硅配体制备。
  • [EN] BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
    申请人:DOW SILICONES CORP
    公开号:WO2020142370A1
    公开(公告)日:2020-07-09
    A branched organosilicon compound ("compound") having the general formula (R1)3Si- X-Y is provided. In the formula: each R1 is selected from R and -OSi(R4)3, with the proviso that at least one R1 is -OSi(R4)3; each R is independently a substituted or unsubstituted hydrocarbyl group; each R4 is selected from R, -OSi(R5)3, and -[OSiR2]mOSiR3; each R5 is selected from R, -OSi(R6)3, and -[OSiR2]mOSiR3; each R6 is selected from R and -[OSiR2]mOSiR3; with the proviso that at least one of R4, R5 and R6 is -[OSiR2]mOSiR3; 0
    提供具有一般式(R1)3Si-X-Y的分支有机硅化合物(“化合物”)。在该式中:每个R1从R和-OSi(R4)3中选择,但至少有一个R1为-OSi(R4)3;每个R都是独立的取代或未取代的烃基团;每个R4从R、-OSi(R5)3和-[OSiR2]mOSiR3中选择;每个R5从R、-OSi(R6)3和-[OSiR2]mOSiR3中选择;每个R6从R和-[OSiR2]mOSiR3中选择;但至少有一个R4、R5和R6为-[OSiR2]mOSiR3;0
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