L-beta-homoalanyl-L-beta-homoleucine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-beta-homoalanyl-L-beta-homoleucine
• 英文别名: (3S)-3-[[(3S)-3-azaniumylbutanoyl]amino]-5-methylhexanoate
• 化学式: C₁₁H₂₂N₂O₃
• 分子量: 230.307
• InChiKey: YVNOSMHDDYFOEO-IUCAKERBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  96.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Boc-β³hAla-β³hLeu-OH 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 L-beta-homoalanyl-L-beta-homoleucine
  参考文献：
  名称：

  β- and γ-Di- and Tripeptides as Potential Substrates for the Oligopeptide Transporter hPepT1

  摘要：

  The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and are transported across the cell monolayers. These two are less-efficient substrates than alpha-peptides. Larger derivatives than beta-dipeptides do not act as hPepT1 substrates, but instead, they appear to be substrates for P-glycoprotein efflux.

  DOI：

  10.1021/jm070148u

文献信息

• β- and γ-Di- and Tripeptides as Potential Substrates for the Oligopeptide Transporter hPepT1
  作者：Ina Hubatsch、Per I. Arvidsson、Dieter Seebach、Kristina Luthman、Per Artursson

  DOI：10.1021/jm070148u

  日期：2007.10.1

  The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and are transported across the cell monolayers. These two are less-efficient substrates than alpha-peptides. Larger derivatives than beta-dipeptides do not act as hPepT1 substrates, but instead, they appear to be substrates for P-glycoprotein efflux.