N-花生四烯酸牛磺酸 | 119959-65-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-花生四烯酸牛磺酸
• 英文名称: N-arachidonoyl taurine
• 英文别名: N-Arachidonoyl-L-taurine；2-[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]amino]ethanesulfonic acid
• CAS: 119959-65-8
• 化学式: C₂₂H₃₇NO₄S
• 分子量: 411.606
• InChiKey: YUNYSWCRLRYOPO-DOFZRALJSA-N

物化性质

• 溶解度：
  DMF：10mg/mL； DMSO：20mg/mL； PBS（pH 7.2）：1.5 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Ligand for G-protein coupled receptor GPR72 and uses thereof
  申请人：Euroscreen S.A.

  公开号：EP1867994A2

  公开（公告）日：2007-12-19

  The present invention relates to methods, reagents and kits for detecting of GPR72 polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against GPR72. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of GPR72 polypeptide signalling.

  本发明涉及检测样品中 GPR72 多肽活性和鉴定调节多肽活性的制剂的方法、试剂和试剂盒。本发明还涉及针对 GPR72 的抗体。本发明还涉及用于预防、治疗和/或缓解以 GPR72 多肽信号失调为特征的疾病或紊乱的物质。
• Pharmaceutical emulsion composition and use thereof
  申请人：College of Pharmacy of Taif University

  公开号：EP2653156A1

  公开（公告）日：2013-10-23

  The present invention relates to a pharmaceutical emulsion composition comprising: at least one drug, at least one amino acid, at least one fatty acid and at least one surfactant, wherein the amino acid, the fatty acid and the surfactant form micelles and the drug is encapsulated into the micelles and its use as a medicament, in particular for oral administration in treatment of hyperglycemia and diabetes.

  本发明涉及一种药用乳液组合物，该组合物包含：至少一种药物、至少一种氨基酸、至少一种脂肪酸和至少一种表面活性剂，其中氨基酸、脂肪酸和表面活性剂形成胶束，药物被包裹在胶束中，并用作药物，特别是用于口服治疗高血糖和糖尿病。
• METHODS FOR MODULATING IKS CHANNEL ACTIVITY
  申请人：ELINDER Fredrik

  公开号：US20170216240A1

  公开（公告）日：2017-08-03

  Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“PUFAs”) to modulate I ks channels to treat conditions associated with a disruption in I ks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pK a values, which can activate (i.e., open) I Ks channels, and positively charged PUFAs that can inhibit (i.e., close) I KS channels.
• US7824866B2
  申请人：——

  公开号：US7824866B2

  公开（公告）日：2010-11-02
• [EN] METHODS FOR MODULATING IKS CHANNEL ACTIVITY<br/>[FR] PROCÉDÉS PERMETTANT DE MODULER L'ACTIVITÉ DES CANAUX IKS
  申请人：UNIV MIAMI

  公开号：WO2016022567A2

  公开（公告）日：2016-02-11

  Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof ("PUFAs") to modulate Iks channels to treat conditions associated with a disruption in Iks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pKa values, which can activate (i.e., open) IKs channels, and positively charged PUFAs that can inhibit (i.e., close) IKS channels.