N-methylbenzenecarbohydrazoyl chloride | 106675-53-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methylbenzenecarbohydrazoyl chloride
• 英文别名: (Z)-N-methylbenzenecarbohydrazonoyl chloride
• CAS: 106675-53-0
• 化学式: C₈H₉ClN₂
• 分子量: 168.626
• InChiKey: XOORIRQYIIFMBQ-FLIBITNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-benzylidene-2-methylhydrazine 、 N-methylbenzenecarbohydrazoyl chloride 在 三乙胺 作用下， 以 氯仿 为溶剂， 以55%的产率得到1,4-dimethyl-3,6-diphenyl-1,2,3,4-tetrahydro-s-tetrazine
  参考文献：
  名称：

  El-Abadelah, Mustafa M.; Hussein, Ahmad Q.; Saadeh, Haythem A., Heterocycles, 1991, vol. 32, # 6, p. 1063 - 1079

  摘要：

  DOI：

文献信息

• Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators
  申请人：Arrhenius Thomas

  公开号：US20080070869A1

  公开（公告）日：2008-03-20

  The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

  本发明涉及新型化合物(I)、它们的前药以及药学上可接受的盐，以及含有这种化合物的药物组合物，用于治疗某些代谢性疾病和通过抑制麦芽酰辅酶A脱羧酶(malonyl-CoA decarboxylase，MCD)酶的抑制而调节的疾病。特别地，本发明涉及化合物和组合物，以及通过抑制麦芽酰辅酶A脱羧酶的方法预防、管理和治疗心血管疾病、糖尿病、酸中毒、癌症和肥胖症。
• Triazole derivative, and light-emitting element, light-emitting device, and electronic device with the use of triazole derivative
  申请人：Semiconductor Energy Laboratory Co., Ltd.

  公开号：US10790451B2

  公开（公告）日：2020-09-29

  It is an object of the present invention to provide a novel triazole derivative. Further, it is another object of the present invention to provide a light-emitting element having high luminous efficiency with the use of the novel triazole derivative. Moreover, it is still another object of the present invention to provide a light-emitting device and electronic devices which have low power consumption. A light-emitting element having high luminous efficiency can be manufactured with the use of a triazole derivative which is a 1,2,4-triazole derivative, in which an aryl group or a heteroaryl group is bonded to each of 3-position, 4-position, and 5-position, and in which any one of the aryl group or heteroaryl group has a 9H-carbazol-9-yl group.

  本发明的一个目的是提供一种新型三唑衍生物。此外，本发明的另一个目的是利用新型三唑衍生物提供一种发光效率高的发光元件。此外，本发明的另一个目的是提供一种低功耗的发光器件和电子设备。使用一种三唑衍生物可以制造出具有高发光效率的发光元件，该衍生物为 1,2,4-三唑衍生物，其中芳基或杂芳基分别键合在 3-位、4-位和 5-位上，并且其中任何一个芳基或杂芳基具有 9H-咔唑-9-基团。
• GRASHEY, R.;STOECKLE, B.;ZAHN, W., CHEM.-ZTG, 1985, 109, N 10, 350-351
  作者：GRASHEY, R.、STOECKLE, B.、ZAHN, W.

  DOI：——

  日期：——
• US7279477B2
  申请人：——

  公开号：US7279477B2

  公开（公告）日：2007-10-09
• El-Abadelah, Mustafa M.; Hussein, Ahmad Q.; Saadeh, Haythem A., Heterocycles, 1991, vol. 32, # 6, p. 1063 - 1079
  作者：El-Abadelah, Mustafa M.、Hussein, Ahmad Q.、Saadeh, Haythem A.

  DOI：——

  日期：——