(2S)-2-amino-N-(5-fluoro-2,4-dinitrophenyl)-3-methylbutanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-N-(5-fluoro-2,4-dinitrophenyl)-3-methylbutanamide
• 化学式: C11H13FN4O5
• 分子量: 300.24
• InChiKey: IPCVWUOHBRELDG-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Compounds potentiating the activity of antifungal drugs
  申请人：Fundacion MEDINA. Centro de Excelencia en Investigacion de Medicamentos Innovadores en Andalucia

  公开号：EP2792683A1

  公开（公告）日：2014-10-22

  Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and A take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly as agents able to potentiate the effect of antifungal drugs.

  通式(I)化合物 其中 R1、R2、R3、R4、R5 和 A 具有不同的含义，含有它们的药物组合物及其在医学中的用途，尤其是作为能够增强抗真菌药物效果的制剂。
• Peptides having antimicrobial activity and new enzyme capable of converting L-configured residue in D-configured amino acid in a peptide
  申请人：INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

  公开号：US10981957B2

  公开（公告）日：2021-04-20

  The present invention relates to a new class of peptides having antibacterial activity and presenting D-amino acids and their uses. It also relates to a new enzyme presenting a peptide epimerase activity in vitro and in vivo, thereby being useful for modifying peptides in order to change the amino acid configuration from L to D.

  本发明涉及一类具有抗菌活性并含有 D-氨基酸的新型肽及其用途。本发明还涉及一种新的酶，这种酶在体外和体内具有肽缩合酶活性，因此可用于修饰肽，将氨基酸构型从 L 转变为 D。
• NEW PEPTIDES HAVING ANTIMICROBIAL ACTIVITY AND NEW ENZYME CAPABLE OF CONVERTING L-CONFIGURED RESIDUE IN D-CONFIGURED AMINO ACID IN A PEPTIDE
  申请人：INSTITUTE NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

  公开号：US20180346526A1

  公开（公告）日：2018-12-06

  The present invention relates to a new class of peptides having antibacterial activity and presenting D-amino acids and their uses. It also relates to a new enzyme presenting a peptide epimerase activity in vitro and in vivo, thereby being useful for modifying peptides in order to change the amino acid configuration from L to D.
• [EN] COMPOUNDS POTENTIATING THE ACTIVITY OF ANTIFUNGAL DRUGS<br/>[FR] COMPOSÉS POTENTIALISANT L'ACTIVITÉ DE MÉDICAMENTS ANTIFONGIQUES
  申请人：FUNDACIÓN MEDINA CT DE EXCELENCIA EN INVESTIGACIÓN DE MEDICAMENTOS INNOVADORES EN ANDALUCÍA

  公开号：WO2014170295A1

  公开（公告）日：2014-10-23

  Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and A take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly as agents able to potentiate the effect of antifungal drugs.