[2-(Trifluoromethoxy)phenyl] hydrogen carbonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [2-(Trifluoromethoxy)phenyl] hydrogen carbonate
• 英文别名: [2-(trifluoromethoxy)phenyl] hydrogen carbonate
• 化学式: C₈H₅F₃O₄
• 分子量: 222.12
• InChiKey: IHQNDEZRTCLHIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics
  申请人：Stingray Therapeutics, Inc.

  公开号：US20200039979A1

  公开（公告）日：2020-02-06

  Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

  取代的-3H-咪唑[4,5-c]吡啶和1H-吡咯[2,3-c]吡啶系列新型胞外核苷酸焦磷酸酶/磷酸二酯酶-1 (ENPP1)及相关化合物，其作为ENPP1的抑制剂是有用的；制造这些化合物的方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与ENPP1功能障碍相关的疾病的方法。
• Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
  申请人：Stingray Therapeutics, Inc.

  公开号：US10689376B2

  公开（公告）日：2020-06-23

  Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

  取代的-3H-咪唑并[4,5-c]吡啶和1H-吡咯并[2,3-c]吡啶系列新型外核苷酸焦磷酸酶/磷酸二酯酶-1（ENPP1）及相关化合物，可用作ENPP1的抑制剂；制造这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与ENPP1功能障碍有关的疾病的方法。
• Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
  申请人：Stingray Therapeutics, Inc.

  公开号：US11142524B2

  公开（公告）日：2021-10-12

  Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

  取代的-3H-咪唑并[4,5-c]吡啶和1H-吡咯并[2,3-c]吡啶系列新型外核苷酸焦磷酸酶/磷酸二酯酶-1（ENPP1）及相关化合物，可用作ENPP1的抑制剂；制造这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与ENPP1功能障碍有关的疾病的方法。
• SUBSTITUTED-3H-IMIDAZO[4,5-C]PYRIDINE AND 1H PYRROLO[2,3-C]PYRIDINE SERIES OF NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR INTERFERON GENES (STING) MODULATORS AS CANCER IMMUNOTHERAPEUTICS
  申请人：Stingray Therapeutics, Inc.

  公开号：EP3829561A1

  公开（公告）日：2021-06-09
• DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME
  申请人：The Research Foundation for the State University of New York

  公开号：US20210032181A1

  公开（公告）日：2021-02-04

  The present invention provides a compound having the structure: a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.