N-[{4-(2-methoxyphenyl)-3-chloro-2-oxo-azetidineimino}propyl]benzotriazole | 1266549-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: N-[{4-(2-methoxyphenyl)-3-chloro-2-oxo-azetidineimino}propyl]benzotriazole
• 英文别名: 1-[3-(Benzotriazol-1-yl)propylamino]-3-chloro-4-(2-methoxyphenyl)azetidin-2-one
• CAS: 1266549-53-4
• 化学式: C₁₉H₂₀ClN₅O₂
• 分子量: 385.853
• InChiKey: LVBCBRSBOIYRDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  72.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(3-(2-(2-methoxybenzylidene)hydrazineyl)propyl)-1H-benzo[d][1,2,3]triazole 、 氯乙酰氯 在 三乙胺 作用下， 反应 0.08h， 以84%的产率得到N-[{4-(2-methoxyphenyl)-3-chloro-2-oxo-azetidineimino}propyl]benzotriazole
  参考文献：
  名称：

  Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: A new class of biological compounds

  摘要：

  We report herein the synthesis and biological activity of a new kind of azetidinone derivatives of benzotriazole. The reaction was carried out by both conventional and microwave methods. The chemical structures of all the synthesized compounds were deduced according to FTIR, H-1 NMR, C-13 NMR and FAB-mass spectral along with microanalytical data. All the synthesized compounds of series 5a-i were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37RV and antimicrobial activity against some selected microorganism. Unexpectedly, some azetidinone derivatives of benzotriazole displayed better activities. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.10.057

文献信息

• Conventional and microwave assisted synthesis of 2-oxo-4-substituted aryl-azetidine derivatives of benzotriazole: A new class of biological compounds
  作者：Adesh Dubey、S.K. Srivastava、S.D. Srivastava

  DOI：10.1016/j.bmcl.2010.10.057

  日期：2011.1

  We report herein the synthesis and biological activity of a new kind of azetidinone derivatives of benzotriazole. The reaction was carried out by both conventional and microwave methods. The chemical structures of all the synthesized compounds were deduced according to FTIR, H-1 NMR, C-13 NMR and FAB-mass spectral along with microanalytical data. All the synthesized compounds of series 5a-i were evaluated for their antitubercular activity against Mycobacterium tuberculosis H37RV and antimicrobial activity against some selected microorganism. Unexpectedly, some azetidinone derivatives of benzotriazole displayed better activities. (C) 2010 Published by Elsevier Ltd.