N-[4-(1H-benzimidazol-2-yl)phenyl]-2-fluoro-5-nitro-benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[4-(1H-benzimidazol-2-yl)phenyl]-2-fluoro-5-nitro-benzamide
• 英文别名: N-[4-(1H-benzimidazol-2-yl)phenyl]-2-fluoro-5-nitrobenzamide
• 化学式: C₂₀H₁₃FN₄O₃
• 分子量: 376.347
• InChiKey: MRLZVYLUESHXOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氟-5-硝基苯甲酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 、 碳酸氢钠 作用下， 以 乙醚 、 苯 为溶剂， 反应 2.0h， 生成 N-[4-(1H-benzimidazol-2-yl)phenyl]-2-fluoro-5-nitro-benzamide
  参考文献：
  名称：

  Synthesis and antimicrobial activities of some new benzimidazole derivatives

  摘要：

  Some benzimidazolylbenzamides were synthesized and their antimicrobial activities against Staphylococcus aureus, Streptococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans evaluated. It was shown that the compound 14 exhibited the best activity against B. subtilis, P. aeruginosa and C. albicans.

  DOI：

  10.1016/s0014-827x(03)00190-3

文献信息

• Synthesis and antimicrobial activities of some new benzimidazole derivatives
  作者：Gülgün Ayhan-Kılcıgil、Nurten Altanlar

  DOI：10.1016/s0014-827x(03)00190-3

  日期：2003.12

  Some benzimidazolylbenzamides were synthesized and their antimicrobial activities against Staphylococcus aureus, Streptococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans evaluated. It was shown that the compound 14 exhibited the best activity against B. subtilis, P. aeruginosa and C. albicans.