Diazoacethylnorleucine methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Diazoacethylnorleucine methyl ester
• 英文别名: methyl 2-amino-2-(2-diazoacetyl)hexanoate
• 化学式: C9H15N3O3
• 分子量: 213.23
• InChiKey: IIECITSIXFJUCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS FOR LYSOSOMAL MODULATION AND METHODS OF USE<br/>[FR] COMPOSÉS POUR MODULATION LYSOSOMALE ET PROCÉDÉS D'UTILISATION
  申请人：UNIV CONNECTICUT

  公开号：WO2009129532A1

  公开（公告）日：2009-10-22

  Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Aβ and other protein and glycoconjugate species are provided. Methods for the treatment of neurodegenerative diseases that involve protein accumulation and aggregation in the brain, such as Alzheimer's, Parkinson's and Huntington's Disease, are also provided.

  提供了用于促进溶酶体过程并从而改善由Aβ和其他蛋白质和糖蛋白物种引起的细胞和功能完整性破坏的化合物。还提供了用于治疗涉及蛋白质在大脑中积累和聚集的神经退行性疾病的方法，如阿尔茨海默病、帕金森病和亨廷顿病。
• Compounds for Lysosomal Modulation and Methods of Use
  申请人：Bahr Ben A.

  公开号：US20090281178A1

  公开（公告）日：2009-11-12

  Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Aβ and other protein and glycoconjugate species are provided. Methods for the treatment of neurodegenerative diseases that involve protein accumulation and aggregation in the brain, such as Alzheimer's, Parkinson's and Huntington's Disease, are also provided.

  提供了有益于促进溶酶体过程，从而缓解由Aβ和其他蛋白质和糖蛋白物种引起的细胞和功能完整性破坏的化合物。还提供了治疗神经退行性疾病的方法，这些疾病涉及蛋白质在大脑中的积累和聚集，如阿尔茨海默病，帕金森病和亨廷顿病。
• Materials for lysosome modulation and methods of use thereof
  申请人：——

  公开号：US20020094958A1

  公开（公告）日：2002-07-18

  Disclosed are compounds and methods of use thereof for modulating lysosome function. Also disclosed is use of the compounds to treat neurodegenerative events and to study lysosomal function.

  公开了调节溶酶体功能的化合物及其使用方法。还公开了使用这些化合物治疗神经退行性疾病和研究溶酶体功能的方法。
• COMPOUNDS FOR LYSOSOMAL MODULATION AND METHODS OF USE
  申请人：University of Connecticut

  公开号：EP2276726A1

  公开（公告）日：2011-01-26
• MATERIALS FOR POSITIVE CATHEPSIN B MODULATION AND METHODS OF USE FOR TREATING MILD COGNITIVE IMPAIRMENT (MCI), EARLY DEMENTIA, A-SYNUCLEINOPATHY, TRAUMATIC BRAIN INJURY, CARDIOMYOPATHY, EYE DISEASE AND SKIN DAMAGE
  申请人：University of North Carolina at Pembroke

  公开号：EP3010532A1

  公开（公告）日：2016-04-27