Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Aβ and other protein and glycoconjugate species are provided. Methods for the treatment of neurodegenerative diseases that involve protein accumulation and aggregation in the brain, such as Alzheimer's, Parkinson's and Huntington's Disease, are also provided.
提供了有益于促进溶酶体过程,从而缓解由Aβ和其他蛋白质和糖蛋白物种引起的细胞和功能完整性破坏的化合物。还提供了治疗神经退行性疾病的方法,这些疾病涉及蛋白质在大脑中的积累和聚集,如阿尔茨海默病,帕
金森病和亨廷顿病。