N-ethyl-L-asparagine | 313269-83-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-ethyl-L-asparagine
• 英文别名: (2S)-4-amino-2-(ethylamino)-4-oxobutanoic acid
• CAS: 313269-83-9；7195-20-2
• 化学式: C₆H₁₂N₂O₃
• 分子量: 160.17
• InChiKey: OLNLSTNFRUFTLM-BYPYZUCNSA-N

物化性质

• 沸点：
  409.9±40.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TUMOR-TARGETING EVALUATION METHODOLOGY AND COMPOUNDS RELATED THERETO
  申请人：GOURDEAU Henriette

  公开号：US20090062255A1

  公开（公告）日：2009-03-05

  The invention relates to a method for evaluating a chemotherapeutic potential of a candidate molecule. In evaluating the candidate molecule, the candidate molecule is tested for its ability to inhibit the in vitro growth of a cancer cell; to bind a cellular receptor produced by a cancer cell, wherein said receptor, such as a peripheral benzodiazepine receptor, is produced in a greater amount by said cancer cell than by a normal cell; and to inhibit the activity of at least one protein member of the MAPK pathway. The invention further relates to dibenzodiazepinone analogues and derivatives thereof.

  该发明涉及一种评估候选分子化疗潜力的方法。在评估候选分子时，将测试候选分子抑制癌细胞体外生长的能力；结合由癌细胞产生的细胞受体，其中所述受体，如外周苯二氮卓受体，由所述癌细胞产生的数量比正常细胞多；并抑制MAPK通路中至少一个蛋白质成员的活性。该发明还涉及二苯二氮卓酮类似物及其衍生物。
• NOVEL ANTIMICROBIAL PEPTIDES
  申请人：He Jian

  公开号：US20080286210A1

  公开（公告）日：2008-11-20

  This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against Streptococcus mutans a common oral pathogen and the causative agent of dental caries.

  这项发明提供了一种新型的抗菌肽，可以有效抑制各种革兰氏阳性细菌的生长和/或增殖。特别是，这些肽对于链球菌变种是有效的，它是一种常见的口腔病原体，也是牙齿龋齿的致病菌。
• [EN] PEPTIDE CONJUGATE AMYLIN AGONISTS AND USES THEREOF<br/>[FR] AGONISTES D'AMYLINE CONJUGUÉS PEPTIDIQUES ET LEURS UTILISATIONS
  申请人：AUCKLAND UNISERVICES LTD

  公开号：WO2020225781A1

  公开（公告）日：2020-11-12

  Disclosed are peptide conjugates that are amylin agonists comprising an amylin peptide comprising or consisting of an amino acid sequence that is an analogue of SEQ ID NO: 1, wherein the peptide comprises a proline residue at positions 25, 28 and 29, wherein at least one amino acid of the peptide is covalently conjugated to a lipid-containing moiety via a sulfur atom of a sulfhydryl group. Also disclosed are pharmaceutical compositions and kits comprising such conjugates, methods of preparing such conjugates, and methods and uses of such agonists.

  本文披露了一种肽共轭物，它们是包含淀粉样蛋白激动剂的肽共轭物，包括一个淀粉样蛋白肽，该肽包括或由一个类似于SEQ ID NO: 1的氨基酸序列组成，其中该肽在第25、28和29位具有脯氨酸残基，其中该肽的至少一个氨基酸通过巯基的硫原子与含脂质基团共价结合。还披露了包括这种共轭物的药物组合物和工具包，制备这种共轭物的方法，以及这种激动剂的方法和用途。
• METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE
  申请人：AMGEN INC.

  公开号：US20150353542A1

  公开（公告）日：2015-12-10

  Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

  提供了一种调节表达感兴趣蛋白的细胞培养物性质的方法。在各种实施方式中，该方法涉及向生长的细胞培养物中添加细胞周期抑制剂。
• TARGETED ANTIMICROBIAL MOIETIES
  申请人：Eckert Randal H.

  公开号：US20100316643A1

  公开（公告）日：2010-12-16

  This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.

  这项发明提供了新型的靶向抗微生物组合物。在各种实施例中，提供了嵌合物，其中包括连接到靶向细菌菌株或物种的肽靶向基团的抗微生物肽。