[(2S,3R)-2-amino-3-hydroxyoctadecyl] 4-(diaminomethylideneamino)-2-(hexadecanoylamino)butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(2S,3R)-2-amino-3-hydroxyoctadecyl] 4-(diaminomethylideneamino)-2-(hexadecanoylamino)butanoate
• 化学式: C₃₉H₇₉N₅O₄
• 分子量: 682.1
• InChiKey: GYOHPRCBBMIPRN-LOZVQPLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.9
• 重原子数：
  48
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Amino acid lipids and uses thereof
  申请人：Quay Steven C.

  公开号：US20110177160A1

  公开（公告）日：2011-07-21

  This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本文披露了一系列氨基酸脂类化合物和组合物，可用于药物传递、治疗、疾病和病况的诊断和治疗。氨基酸脂类化合物和组合物可用于将各种药剂如核酸治疗剂传递至细胞、组织、器官和受试者。
• AMINO ACID LIPIDS AND USES THEREOF
  申请人：Marina Biotech, Inc.

  公开号：US20140037714A1

  公开（公告）日：2014-02-06

  This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本公开提供了一系列氨基酸脂质化合物和组合物，可用于药物传递、治疗以及疾病和病症的诊断和治疗。氨基酸脂质化合物和组合物可用于向细胞、组织、器官和受试者传递各种药物，例如核酸治疗药物。
• TYROSINE-BASED LIPIDS FOR DELIVERY OF THERAPEUTICS
  申请人：Marina Biotech, Inc.

  公开号：US20160206739A1

  公开（公告）日：2016-07-21

  This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本披露提供了一系列酪氨酸氨基酸脂类化合物和组合物，可用于药物输送、治疗以及疾病和病症的诊断和治疗。这些氨基酸脂类化合物和组合物可用于将各种药剂如核酸治疗剂输送至细胞、组织、器官和受试者。
• Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics
  申请人：Polisky Barry A.

  公开号：US20100112042A1

  公开（公告）日：2010-05-06

  Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition. An efficiency for delivering a drug cargo is provided. Compositions can include a liposome containing one or more carrier particles, each carrier particle having an active agent and a peptide, wherein the ratio of the mass of the peptide plus the mass of the liposome to the mass of the active agent is less than about 15.
• PROCESSES AND COMPOSITIONS FOR LIPOSOMAL AND EFFICIENT DELIVERY OF GENE SILENCING THERAPEUTICS
  申请人：Marina Biotech, Inc.

  公开号：US20150209283A1

  公开（公告）日：2015-07-30

  Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition.