2-Amino-1-(4-benzoyl-piperazin-1-yl)-ethanone | 671212-20-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-1-(4-benzoyl-piperazin-1-yl)-ethanone
• 英文别名: 2-Amino-1-(4-benzoylpiperazin-1-yl)ethanone
• CAS: 671212-20-7
• 化学式: C₁₃H₁₇N₃O₂
• mdl: MFCD04116662
• 分子量: 247.297
• InChiKey: LGWCWADFPBRGMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  异丙基磺酰氯 、 2-Amino-1-(4-benzoyl-piperazin-1-yl)-ethanone 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以24%的产率得到Propane-2-sulfonic acid [2-(4-benzoyl-piperazin-1-yl)-2-oxo-ethyl]-amide
  参考文献：
  名称：

  Structure–activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs

  摘要：

  Structure-activity relationships on two novel potent cognition enhancing drugs, unifiram (DM232, 1) and sunifiram (DM235, 2), are reported. Although none of the compounds synthesised reached the potency of the parent drugs, some fairly active compounds have been identified that may represent new leads to develop other cognition enhancing drugs. An interesting result of this research is the identification of two compounds (13 and 14) that are endowed with amnesing activity (the opposite of the activity of the original molecules) and are nearly equipotent to scopolamine. Moreover, two compounds of the series (5 and 6) were found endowed with analgesic activity on a rat model of neuropathic pain at the dose of 1 mg/kg. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.025
• 作为产物：
  描述：

  (2-氧代-2-哌嗪-1-乙基)-氨基甲酸叔丁酯 在 盐酸 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 48.0h， 生成 2-Amino-1-(4-benzoyl-piperazin-1-yl)-ethanone
  参考文献：
  名称：

  Structure–activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs

  摘要：

  Structure-activity relationships on two novel potent cognition enhancing drugs, unifiram (DM232, 1) and sunifiram (DM235, 2), are reported. Although none of the compounds synthesised reached the potency of the parent drugs, some fairly active compounds have been identified that may represent new leads to develop other cognition enhancing drugs. An interesting result of this research is the identification of two compounds (13 and 14) that are endowed with amnesing activity (the opposite of the activity of the original molecules) and are nearly equipotent to scopolamine. Moreover, two compounds of the series (5 and 6) were found endowed with analgesic activity on a rat model of neuropathic pain at the dose of 1 mg/kg. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.025

文献信息

• NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
  申请人：BISCHOFF Alexander

  公开号：US20090221583A1

  公开（公告）日：2009-09-03

  The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

  本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的吡啶二元衍生物。本发明还涉及制备该化合物的方法、含有该化合物的组合物以及使用该化合物进行治疗的方法。
• US7842696B2
  申请人：——

  公开号：US7842696B2

  公开（公告）日：2010-11-30